Isaacson P, Jones D B, Sworn M J, Wright D H
J Clin Pathol. 1982 May;35(5):510-6. doi: 10.1136/jcp.35.5.510.
Tumour cells from three cases of malignant histiocytosis of the intestine (MHI) have been studied immunologically and cytochemically. The cells did not form E rosettes and showed weak Fc gamma surface receptors. They contained non-specific esterase and acid phosphatase in diffuse granular distribution. In one case tumour cells showed no staining by an immunoperoxidase technique with two monoclonal anti-T cell antibodies but positive staining with a monoclonal anti-Ia-like antibody. The malignant cells from all three cases could be shown to contain alpha-1-antitrypsin. These are the first cases of MHI to have been studied in this way and the results confirm the true histiocytic--that is, monocyte/macrophage, derivation of the tumour cells in this disease.
对3例肠道恶性组织细胞增多症（MHI）的肿瘤细胞进行了免疫和细胞化学研究。这些细胞不形成E花环，且显示出较弱的Fcγ表面受体。它们含有弥漫性颗粒分布的非特异性酯酶和酸性磷酸酶。在1例中，肿瘤细胞用两种抗T细胞单克隆抗体进行免疫过氧化物酶技术检测时无染色，但用一种抗Ia样单克隆抗体检测呈阳性染色。所有3例的恶性细胞均显示含有α1抗胰蛋白酶。这是首次以这种方式研究的MHI病例，结果证实了该疾病中肿瘤细胞真正来源于组织细胞，即单核细胞/巨噬细胞。
