克拉维酸对16种针对嗜肺军团菌测试的抗菌药物最低抑菌浓度的影响。
Effect of clavulanic acid on minimal inhibitory concentrations of 16 antimicrobial agents tested against Legionella pneumophila.
作者信息
Pohlod D J, Saravolatz L D, Quinn E L, Somerville M M
出版信息
Antimicrob Agents Chemother. 1980 Aug;18(2):353-4. doi: 10.1128/AAC.18.2.353.
Abstract
A total of 15 Legionella pneumophilia isolated were tested against 16 antimicrobial agents used singly and in combination with clavulanic acid. When combined with clavulanic acid, 4 of the 16 antimicrobial agents produced no enhanced effect. However, the minimal inhibitory concentrations of 12 of the antimicrobial agents were reduced by one-half to one-third when in combination with clavulanic acid. These reductions reflected only a one-dilution decrease, however, in the original minimal inhibitory concentrations. Thus, clavulanic acid combinations appear to be only nominally effective beta-lactamase inhibitors against L. pneumophilia.
摘要
总共对15株分离出的嗜肺军团菌进行了测试，检测其对16种单独使用以及与克拉维酸联合使用的抗菌药物的敏感性。与克拉维酸联合使用时，16种抗菌药物中有4种未产生增强效果。然而，12种抗菌药物与克拉维酸联合使用时，其最低抑菌浓度降低了二分之一至三分之一。不过，这些降低仅反映了原始最低抑菌浓度降低了一个稀释度。因此，克拉维酸联合制剂似乎只是对嗜肺军团菌有名义上有效的β-内酰胺酶抑制剂。
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