银屑病和银屑病关节炎中的循环免疫复合物、血清免疫球蛋白及急性期蛋白
Circulating immune complexes, serum immunoglobulins, and acute phase proteins in psoriasis and psoriatic arthritis.
作者信息
Laurent M R, Panayi G S, Shepherd P
出版信息
Ann Rheum Dis. 1981 Feb;40(1):66-9. doi: 10.1136/ard.40.1.66.
Abstract
Raised levels of circulating immune complexes were found in the plasma of 47% of patients with psoriasis and in 58% of those with psoriatic arthritis. The mean levels were significantly raised when compared with normals, but there was no difference between the 2 patient groups. The levels of acute phase proteins (C-reactive protein, fibrinogen, alpha-1-antitrypsin, and the 9th component of complement) were normal in those patients with psoriasis but were significantly raised in patients with psoriatic arthritis. Serum immunoglobulin G and A levels were equally raised in both patient groups, immunoglobulin M being normal. C-reactive protein and fibrinogen gave the best correlation with the clinical index of disease activity.
摘要
在47%的银屑病患者和58%的银屑病关节炎患者的血浆中发现循环免疫复合物水平升高。与正常人相比，平均水平显著升高，但这两组患者之间没有差异。银屑病患者的急性期蛋白（C反应蛋白、纤维蛋白原、α-1抗胰蛋白酶和补体第九成分）水平正常，但银屑病关节炎患者的急性期蛋白水平显著升高。两组患者的血清免疫球蛋白G和A水平均同样升高，免疫球蛋白M正常。C反应蛋白和纤维蛋白原与疾病活动临床指标的相关性最佳。
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