Ludivico C L, Zweiman B, Myers A R, Hebert J, Green P A
J Rheumatol. 1980 Nov-Dec;7(6):843-9.
In a retrospective study of 71 patients with systemic lupus erythematosus (SLE), a large number of clinical and laboratory variables were studied in order to determine their predictive value of morbidity and mortality. Patients were followed for an average of 57 months. Anti-DNA antibody, hemoglobin and creatinine levels at initial evaluation correlated significantly (p less than 0.05) for subsequent course of SLE, although each parameter was not a good predictor for final outcome. Anti-DNA correlated better with subsequent course in patients who were diagnosed within 12 months of the initial evaluation. By comparison, other measured parameters were not predictive at all. Anti-DNA, hemoglobin, creatinine and C3 levels at the time of most recent evaluation (date last seen) correlated strongly (p less than 0.01-p less than 0.001) with concurrent clinical status.
在一项对71例系统性红斑狼疮（SLE）患者的回顾性研究中，研究了大量临床和实验室变量，以确定它们对发病率和死亡率的预测价值。患者平均随访57个月。初始评估时的抗DNA抗体、血红蛋白和肌酐水平与SLE的后续病程显著相关（p小于0.05），尽管每个参数都不是最终结局的良好预测指标。抗DNA与初始评估后12个月内确诊的患者的后续病程相关性更好。相比之下，其他测量参数根本没有预测性。最近一次评估（最后一次就诊日期）时的抗DNA、血红蛋白、肌酐和C3水平与同时期的临床状态密切相关（p小于0.01 - p小于0.001）。
