怀孕对小鼠甲病毒免疫刺激的影响。
Effect of pregnancy on stimulation of alphavirus immunity in mice.
作者信息
Milner A R, Marshall I D, Mullbacher A
出版信息
J Virol. 1984 Apr;50(1):73-6. doi: 10.1128/JVI.50.1.73-76.1984.
Abstract
The state of pregnancy was associated with a marked enhancement of both proliferative and cytotoxic T cell antiviral immune responses after infection of mice with avirulent Semliki Forest virus. Strong responses were obtained from the spleen and the para-aortic lymph nodes that drain the uterus. This immune enhancement seemed to be in response to the increased antigenic challenge that originated from infected placental and fetal tissue and was released during the process of abortion. Immune enhancement was not observed in pregnant mice similarly infected with Ross River virus, which also established an intrauterine infection but does not cause abortion.
摘要
在用无毒力的Semliki森林病毒感染小鼠后，怀孕状态与增殖性和细胞毒性T细胞抗病毒免疫反应的显著增强有关。从引流子宫的脾脏和主动脉旁淋巴结获得了强烈的反应。这种免疫增强似乎是对来自受感染胎盘和胎儿组织并在流产过程中释放的抗原挑战增加的反应。在用罗斯河病毒进行类似感染的怀孕小鼠中未观察到免疫增强，罗斯河病毒也会引发子宫内感染，但不会导致流产。
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