Swaak A J, Groenwold J, Aarden L A, Statius van Eps L W, Feltkamp E W
Ann Rheum Dis. 1982 Aug;41(4):388-95. doi: 10.1136/ard.41.4.388.
In a prospective longitudinal study 130 patients with systemic lupus erythematosus (SLE) were studied at least monthly for a relationship between the anti-dsDNA levels and disease activity. We observed 13 patients who developed 15 periods of exacerbations of their disease. All 15 exacerbations were preceded by a continuous increase of the anti-dsDNA levels. In 13 of the 15 exacerbations studied the exacerbation was preceded by an increase of anti-dsDNA with a doubling time (T2) of less than 6 weeks; in 4 of the 5 other exacerbations the T2 was less than 10 weeks. Four other patients with an increase of the anti-dsDNA levels showed no exacerbation. In these 4 patients the T2 was larger than 10 weeks. The other 113 patients did not show an increase of anti-dsDNA over the 2 years of monitoring and showed no signs of serious disease activity (no major symptoms). These observations suggest that an SLE patient who is followed up frequently and who shows a continuous increase of anti-dsDNA witha T2 shorter than 10 weeks is bound to develop an exacerbation.
在一项前瞻性纵向研究中，对130例系统性红斑狼疮（SLE）患者进行了至少每月一次的随访，以研究抗双链DNA（anti-dsDNA）水平与疾病活动度之间的关系。我们观察到13例患者出现了15次疾病加重期。所有15次加重期之前均有anti-dsDNA水平持续升高。在研究的15次加重期中，有13次加重期之前anti-dsDNA水平升高，其倍增时间（T2）小于6周；在其他5次加重期中，有4次T2小于10周。另外4例anti-dsDNA水平升高的患者未出现疾病加重。这4例患者的T2大于10周。在2年的监测期内，其他113例患者的anti-dsDNA水平未升高，也未出现严重疾病活动的迹象（无主要症状）。这些观察结果表明，频繁随访且anti-dsDNA持续升高、T2短于10周的SLE患者必然会出现疾病加重。
