Youinou P Y, Irving W L, Shipley M, Hayes J, Lydyard P M
Clin Exp Immunol. 1984 Jan;55(1):91-8.
Peripheral blood lymphocytes and in some cases synovial eluate cells from 51 patients with rheumatoid arthritis (RA), were analysed for the percentages of cells bearing surface light chains (total B cells), IgM and IgD. In addition, their capacity to form rosettes with mouse erythrocytes (mRFC)--a property of a B cell subpopulation--was determined. Activity of the disease was assessed by clinical and laboratory criteria and classified as very active, moderately active and inactive. Normal, age and sex matched individuals and a group of patients with a variety of other rheumatological disorders, were used as control populations. Although there was no significant difference in percentages of total B cells in any of the groups compared with normal controls, there was a small but significant increase in the ratio of cells bearing IgM to those bearing IgD in patients with very active disease. This was paralleled by a significant decrease in the mRFC in this disease activity group. Patients with inactive disease showed no change in their proportions of IgM:IgD, but did show a significant increase in mRFC. These results are discussed in terms of the presence of activated B cells in patients with very active RA.
对51例类风湿性关节炎（RA）患者的外周血淋巴细胞以及某些情况下的滑膜洗脱液细胞进行分析，以确定携带表面轻链的细胞（总B细胞）、IgM和IgD的百分比。此外，还测定了它们与小鼠红细胞形成花环的能力（mRFC）——这是B细胞亚群的一种特性。通过临床和实验室标准评估疾病活动度，并将其分为非常活跃、中度活跃和不活跃。正常、年龄和性别匹配的个体以及一组患有各种其他风湿性疾病的患者作为对照人群。尽管与正常对照组相比，任何一组中的总B细胞百分比均无显著差异，但在疾病非常活跃的患者中，携带IgM的细胞与携带IgD的细胞之比有小幅但显著的增加。这与该疾病活动组中mRFC的显著降低相平行。疾病不活跃的患者IgM:IgD比例无变化，但mRFC确实显著增加。根据疾病非常活跃的RA患者中存在活化B细胞这一情况对这些结果进行了讨论。
