O'Kennedy R, Smyth H, Corrigan A, Clyness M
Eur J Cancer Clin Oncol. 1982 May;18(5):437-46. doi: 10.1016/0277-5379(82)90111-0.
Unfractionated normal blood lymphocytes (predominantly T lymphocytes) showed significantly elevated total and neuraminidase-susceptible sialic acid compared with CLL lymphocytes (predominantly B lymphocytes). T-enriched fractions from normal blood contained about three-fold the sialic acid content of the corresponding T-depleted fractions, and similarly low values were also obtained for T-depleted fractions from tonsils. Thus the reduced sialic acid levels in CLL lymphocytes appear to be due to their B cell nature. In contrast to the situation in normal peripheral venous blood, tonsillar T and B cells did not differ markedly in sialic acid content, suggesting that for T cells maturity and/or location in vivo are important determinants of this parameters. Results with calf thymocytes were in agreement with this. Sialic acid was estimated in malignant B and T lymphoblasts. Shedding of sialic acid-containing moieties from lymphocytes was also examined.
与慢性淋巴细胞白血病（CLL）淋巴细胞（主要是B淋巴细胞）相比，未分级的正常血液淋巴细胞（主要是T淋巴细胞）显示总唾液酸和对神经氨酸酶敏感的唾液酸显著升高。正常血液中富含T细胞的组分所含唾液酸含量约为相应T细胞耗竭组分的三倍，扁桃体T细胞耗竭组分也得到了类似的低值。因此，CLL淋巴细胞中唾液酸水平降低似乎是由于其B细胞性质。与正常外周静脉血的情况相反，扁桃体T细胞和B细胞的唾液酸含量没有显著差异，这表明对于T细胞来说，成熟度和/或体内位置是该参数的重要决定因素。小牛胸腺细胞的结果与此一致。对恶性B淋巴细胞和T淋巴母细胞中的唾液酸进行了估计。还检测了淋巴细胞中含唾液酸部分的脱落情况。
