黑色素瘤病例中T淋巴细胞上酰基神经氨酸的改变。
Alterations of acyl-neuraminic acids on T-lymphocytes in cases of melanoma.
作者信息
Holzhauser R, Faillard H, Klose W, Huber W, Stickl H, Landthaler M
机构信息
Universität des Saarlandes, Biochemie.
出版信息
Klin Wochenschr. 1988 Jun 15;66(12):540-4. doi: 10.1007/BF01736523.
PMID:3262185
Abstract
Content and distribution of the different sialic acids on human lymphocytes, isolated from 7-10 ml of fresh human blood, were determined using microanalytical methods, such as HPLC and a colorimetric test. Comparison of the data of patients with melanoma with those of healthy persons shows an evident increase of the sialic acid content combined with a shift of the sialic acid distribution to higher O-acetylated derivatives.
摘要
使用高效液相色谱法（HPLC）和比色试验等微量分析方法，测定了从7 - 10毫升新鲜人血中分离出的人淋巴细胞上不同唾液酸的含量和分布。黑色素瘤患者与健康人的数据比较显示，唾液酸含量明显增加，同时唾液酸分布向更高O - 乙酰化衍生物转移。
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