营养变异型链球菌中的青霉素耐受性
Penicillin tolerance in nutritionally variant streptococci.
作者信息
Holloway Y, Dankert J
出版信息
Antimicrob Agents Chemother. 1982 Dec;22(6):1073-5. doi: 10.1128/AAC.22.6.1073.
Abstract
Eleven strains of nutritionally variant streptococci were tested for their susceptibility to penicillin by a broth dilution method. All minimal inhibitory concentrations were low. It was found that plates containing only vitamin B6 (pyridoxal HCl) and cysteine did not reveal true minimal bactericidal concentrations. When penicillinase was added to the subculture medium and a staphylococcal streak was made across the plates, all 11 strains were found to have high minimal bactericidal concentrations and were shown to be tolerant to penicillin.
摘要
采用肉汤稀释法对11株营养变异型链球菌进行了青霉素敏感性测试。所有最低抑菌浓度均较低。发现仅含维生素B6（盐酸吡哆醛）和半胱氨酸的平板未显示出真正的最低杀菌浓度。当在传代培养基中加入青霉素酶并在平板上划一条葡萄球菌划线时，发现所有11株菌株均具有较高的最低杀菌浓度，且对青霉素耐受。
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