具有淋巴细胞激活因子活性的中性粒细胞产物。
Neutrophil product with lymphocyte activating factor activity.
作者信息
Harris P J
出版信息
Clin Exp Immunol. 1982 Dec;50(3):474-8.
Abstract
Lymphocyte activating factor (LAF) is a monocyte derived product which has the ability to enhance the proliferative response of murine thymocytes to the T cell mitogen concanavalin A (Con A). In this report, we have demonstrated that supernatants from normal human polymorphonuclear cells (PMNs) and from granules obtained from PMNs exhibit activity identical to LAF when tested against mouse thymocytes. Our results suggest that PMNs may release factors essential for T cell activation and thus, like monocytes, may serve as important accessory cells in the development of T cell-dependent immunity.
摘要
淋巴细胞激活因子（LAF）是一种单核细胞衍生产物，它能够增强小鼠胸腺细胞对T细胞有丝分裂原刀豆球蛋白A（Con A）的增殖反应。在本报告中，我们已证明，当针对小鼠胸腺细胞进行测试时，正常人多形核细胞（PMN）的上清液以及从PMN获得的颗粒表现出与LAF相同的活性。我们的结果表明，PMN可能释放T细胞激活所必需的因子，因此，与单核细胞一样，可能在T细胞依赖性免疫的发展中作为重要的辅助细胞。
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本文引用的文献
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The antigenic characteristics of hematopoietic stem cells.造血干细胞的抗原特性。
N Engl J Med. 1981 Jul 2;305(1):17-25. doi: 10.1056/NEJM198107023050104.
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Immunology. 1969 Jan;16(1):107-21.
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Isolation of leucocytes from human blood. A two-phase system for removal of red cells with methylcellulose as erythrocyte-aggregating agent.从人血中分离白细胞。一种以甲基纤维素作为红细胞聚集剂去除红细胞的两相系统。
Scand J Clin Lab Invest Suppl. 1968;97:9-29.
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