乙醛和双硫仑对离体灌注兔肝白蛋白合成的影响。

The effects of acetaldehyde and disulfiram on albumin synthesis in the isolated perfused rabbit liver.

作者信息

Rothschild M A, Oratz M, Schreiber S S, Mongelli J

出版信息

Alcohol Clin Exp Res. 1980 Jan;4(1):30-3. doi: 10.1111/j.1530-0277.1980.tb04787.x.

DOI:10.1111/j.1530-0277.1980.tb04787.x

Abstract

Acetaldehyde infusions inhibit albumin synthesis in the liver from fed donors but not in the livers from fasted donors. The inhibition of acetaldehyde metabolism with 4-MP and disulfiram reverses this finding, suggesting that acetaldehyde per se is not the toxic agent. Disulfiram stimulates albumin synthesis in livers from fasted donors, and the presence of acetaldehyde does not prevent this process. The effects of ethanol infusions cannot be explained as due to the presence of acetaldehyde; some intermediate metabolic step may be the basis of the inhibition of albumin production and polysome disaggregation in the presence of ethanol.

摘要

乙醛输注会抑制进食供体肝脏中的白蛋白合成，但不会抑制禁食供体肝脏中的白蛋白合成。用4-甲基吡唑（4-MP）和双硫仑抑制乙醛代谢可逆转这一发现，表明乙醛本身不是毒性因子。双硫仑可刺激禁食供体肝脏中的白蛋白合成，且乙醛的存在并不会阻止这一过程。乙醇输注的影响不能用乙醛的存在来解释；某些中间代谢步骤可能是乙醇存在时白蛋白产生受抑制和多核糖体解聚的基础。