白色念珠菌的脱氧核糖核酸缺陷菌株。
Deoxyribonucleic acid-deficient strains of Candida albicans.
作者信息
Olaiya A F, Steed J R, Sogin S J
出版信息
J Bacteriol. 1980 Mar;141(3):1284-90. doi: 10.1128/jb.141.3.1284-1290.1980.
Abstract
We analyzed a series of germ tube-negative variants isolated from Candida albicans 3153A for deoxyribonucleic acid content. As analyzed by flow microfluorometry, the deoxyribonucleic acid level in these variant strains was 50% of that of the parental strain and equivalent to that of haploid Saccharomyces cerevisiae. This finding was confirmed by comparison of survival rates when exposed to the mutagens ultraviolet light, ethyl methane sulfonate, and methyl methane sulfonate. The diameter of the variant cells as compared to the diameter of the parental 3153A strain showed a relationship similar to that of the diameters of haploid versus diploid S. cerevisiae. These results indicate that those strains may be representative of the imperfect stage of C. albicans.
摘要
我们分析了从白色念珠菌3153A分离出的一系列芽管阴性变体的脱氧核糖核酸含量。通过流式细胞荧光测定法分析，这些变体菌株中的脱氧核糖核酸水平是亲本菌株的50%，与单倍体酿酒酵母的水平相当。通过比较暴露于诱变剂紫外线、甲基磺酸乙酯和甲基磺酸甲酯时的存活率，这一发现得到了证实。与亲本3153A菌株的直径相比，变体细胞的直径显示出与单倍体和二倍体酿酒酵母直径相似的关系。这些结果表明，那些菌株可能代表白色念珠菌的不完全阶段。
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