Lampman R M, Santinga J T, Bassett D R, Block W D, Mercer N, Hook D A, Flora J D, Foss M L
Am J Clin Nutr. 1980 Jun;33(6):1233-43. doi: 10.1093/ajcn/33.6.1233.
Serum lipids, plasma insulin and glucagon, aerobic capacity, and body composition were examined in middle-aged men (X age = 44.2 years) with type IV hyperlipoproteinemia to determine the relative effectiveness of a caloric restricted type IV hyperlipoproteinemia diet (group A) versus physical training plus an isocaloric type IV diet (group B). After 9 weeks of the above interventions, reductions (P less than 0.01) in mean cholesterol levels from 213 to 186 (12% change) and from 205 to 185 mg/dl (9% change), and in triglyceride levels from 332 to 211 (29% change) and from 263 to 138 mg/dl (42% change) were found for groups A and B, respectively. A small reduction in mean fasting insulin level was found only in group B; this reduction appeared inversely associated with increases in aerobic capacity in group B (r = -0.66). Both interventions were without effect on fasting glucagon levels. The physical training program prescribed resulted in a 12% increase in aerobic capacity (group B). Significant mean body weight reductions of 7.7 lb (P less than 0.01) and 2.9 lb (P less than 0.01) were seen for groups A and B, respectively; these absolute body weight reductions differed significantly (P less than 0.05) between groups. Both groups significantly lost body fatness (P less than 0.01). These reductions in body weight and body fatness appeared independent of changes in lipid levels. These results demonstrate that both interventions reduce serum lipids in men with type IV hyperlipoproteinemia but that physical training plus an isocaloric type IV diet may be the more advantageous of the two regimens, since a greater percentage decrease and a more sustained reduction in serum triglyceride levels, and a greater reduction of fasting hyperinsulinemia were observed in group B.
对患有IV型高脂蛋白血症的中年男性（平均年龄=44.2岁）的血清脂质、血浆胰岛素和胰高血糖素、有氧能力及身体成分进行了检测，以确定热量限制的IV型高脂蛋白血症饮食（A组）与体育锻炼加等热量IV型饮食（B组）的相对有效性。在上述干预9周后，A组和B组的平均胆固醇水平分别从213降至186mg/dl（变化12%）和从205降至185mg/dl（变化9%），甘油三酯水平分别从332降至211mg/dl（变化29%）和从263降至138mg/dl（变化42%），均有降低（P<0.01）。仅在B组发现平均空腹胰岛素水平有小幅降低；该降低似乎与B组有氧能力的增加呈负相关（r=-0.66）。两种干预对空腹胰高血糖素水平均无影响。规定的体育锻炼计划使B组的有氧能力提高了12%。A组和B组的平均体重分别显著降低了7.7磅（P<0.01）和2.9磅（P<0.01）；两组之间的绝对体重降低差异显著（P<0.05）。两组的体脂均显著减少（P<0.01）。体重和体脂的这些减少似乎与血脂水平的变化无关。这些结果表明，两种干预均可降低IV型高脂蛋白血症男性的血清脂质，但体育锻炼加等热量IV型饮食可能是两种方案中更具优势的一种，因为B组的血清甘油三酯水平降低百分比更大且降低更持久，空腹高胰岛素血症的降低幅度也更大。
