Bye C E, Cooper J, Empey D W, Fowle A S, Hughes D T, Letley E, O'Grady J
Br Med J. 1980 Jul 19;281(6234):189-90. doi: 10.1136/bmj.281.6234.189.
A total of 466 healthy adults from four different regions of England entered a double-blind, randomised trial to test the effectiveness of an antihistamine (triprolidine) and a decongestant (pseudoephedrine), alone or in combination, in relieving symptoms of the common cold. During the study 199 subjects reported a total of 243 colds. Subjects recorded the severity of 12 symptoms during treatment and noted separately the severity of a further seven symptoms that represented unwanted effects of treatment or served as an index of suggestibility. They were then asked about their overall improvement in symptoms during treatment and whether they thought they had taken placebo. Sneezing, nasal obstruction, and overall response to treatment were significantly improved (p <0.01) with psuedoephedrine or pseudoephedrine and triprolidine compared with placebo.
来自英格兰四个不同地区的466名健康成年人参加了一项双盲随机试验，以测试抗组胺药（曲普利啶）和解充血药（伪麻黄碱）单独使用或联合使用缓解普通感冒症状的有效性。在研究期间，199名受试者报告了总共243次感冒。受试者记录了治疗期间12种症状的严重程度，并分别记录了另外7种症状的严重程度，这些症状代表治疗的不良影响或作为暗示性指标。然后询问他们治疗期间症状的总体改善情况以及是否认为自己服用了安慰剂。与安慰剂相比，伪麻黄碱或伪麻黄碱与曲普利啶联合使用可显著改善打喷嚏、鼻塞和对治疗的总体反应（p<0.01）。
