Bleicher S J, Lee T Y, Bernstein R, Schachter L, Temes R, Krupin T, Santiago J, Becker B, Waltman S R
Diabetes Care. 1980 Jan-Feb;3(1):184-6. doi: 10.2337/diacare.3.1.184.
Thirteen patients were instructed in a technique of self-management of insulin-dependent diabetes mellitus, using multiple home-monitored blood glucose determinations and multiple injections of regular insulin in conjunction with once-daily Ultra Lente insulin. Hemoglobin A1c and quantitative fluorescein fluorophotometry were used to assess blood glucose control and retinal permeability, respectively. In those patients achieving normal blood glucose control, retinal vascular leakage was statistically identical to that of a nondiabetic control population. In those patients less well controlled, retinal permeability did not differ statistically from values observed in a population of insulin-dependent diabetic patients under "standard" control. It is concluded that with "tight" control of blood sugar and normalized A1c hemoglobin, retinal permeability similarly is normalized.
13名患者接受了胰岛素依赖型糖尿病自我管理技术的指导，该技术采用多次家庭监测血糖测定以及多次注射正规胰岛素并结合每日一次的超长效胰岛素。分别使用糖化血红蛋白和定量荧光素荧光光度法来评估血糖控制情况和视网膜通透性。在那些实现血糖正常控制的患者中，视网膜血管渗漏在统计学上与非糖尿病对照人群相同。在那些控制较差的患者中，视网膜通透性与在“标准”控制下的胰岛素依赖型糖尿病患者群体中观察到的值在统计学上没有差异。得出的结论是，通过对血糖进行“严格”控制和使糖化血红蛋白正常化，视网膜通透性同样会正常化。
