Lauritzen T, Frost-Larsen K, Larsen H W, Deckert T
Lancet. 1983 Jan 29;1(8318):200-4. doi: 10.1016/s0140-6736(83)92585-0.
30 insulin-dependent diabetic patients with background retinopathy were randomised to conventional treatment (UCT) or treatment with continuous subcutaneous insulin infusion (CSII). They were followed prospectively for 1 year with fortnightly seven-sample home blood glucose measurements and retinal examinations every 6 months. Mean blood glucose and stable haemoglobin A1c during months 3-12 were significantly lower in the CSII than the UCT group. Retinal morphology deteriorated during the year with no significant differences between UCT and CSII groups. The frequency of deterioration was highest in the CSII group, especially among the 10 patients with best glycaemic control. Proliferative retinopathy developed in 3 patients--2 of these were CSII treated. Retinal function (oscillatory potential, macular recovery time, and posterior vitreous fluorophotometry) improved significantly with CSII treatment and deteriorated significantly with UCT. Changes in retinal function were most pronounced in patients with the best and the poorest regulated glycaemic control.
30名患有背景性视网膜病变的胰岛素依赖型糖尿病患者被随机分为接受传统治疗（UCT）组或持续皮下胰岛素输注（CSII）治疗组。对他们进行了为期1年的前瞻性随访，每两周进行7次家庭血糖测量，每6个月进行一次视网膜检查。在第3至12个月期间，CSII组的平均血糖和稳定血红蛋白A1c显著低于UCT组。一年中视网膜形态恶化，UCT组和CSII组之间无显著差异。恶化频率在CSII组最高，尤其是在血糖控制最佳的10名患者中。3名患者发生了增殖性视网膜病变，其中2名接受CSII治疗。CSII治疗使视网膜功能（振荡电位、黄斑恢复时间和玻璃体后荧光光度法）显著改善，而UCT治疗使其显著恶化。视网膜功能变化在血糖控制最佳和最差的患者中最为明显。
