Everson J, Patterson C C
Clin Chem. 1980 Oct;26(11):1603-7.
We measured lead concentrations in venous blood plasma from two subjects, one having a typical exposure and the other a high exposure to lead. Our preliminary data, obtained by isotope dilution/mass spectrometric techniques in an ultra-clean laboratory, show lead concentrations of 0.02 mug/L and 2 mug/L, respectively, in their blood plasma, and 110 mug/L and 800 mug/L, respectively, in samples of whole blood. These results indicate that plasma lead concentrations previously reported have been overestimated by a large factor, and that further improvements in analytical procedures are needed in most laboratories before data on lead concentratios in blood plasma can be properly interpreted. Our preliminary data indicate a positive correlation between lead intake and lead concentrations in blood plasma.
我们测量了两名受试者静脉血血浆中的铅浓度，其中一名有典型的铅暴露情况，另一名有高铅暴露情况。我们在超净实验室通过同位素稀释/质谱技术获得的初步数据显示，他们血浆中的铅浓度分别为0.02微克/升和2微克/升，全血样本中的铅浓度分别为110微克/升和800微克/升。这些结果表明，先前报道的血浆铅浓度被大幅高估，并且在大多数实验室能够正确解读血浆铅浓度数据之前，分析程序需要进一步改进。我们的初步数据表明铅摄入量与血浆铅浓度之间存在正相关。
