Tolpyshev B A
Farmakol Toksikol. 1980 Mar-Apr;43(2):140-4.
Arrest reaction, circling, cortical spindles induced by electrical stimulation of the caudate nucleus and stereotypy behaviour provoked by threshold doses of amphetamine were recorded in chronic experiments on cats. Sodium hydroxybutyrate and phenibut facilitated motor arrest, while qammalon did not exhibit such an effect. All the substances markedly decreased thresholds of cortical caudate-induced spindles. In contradistinction to gammalon, sodium hydroxybutyrate and phenibut weakened stereotypy behaviour at the same doses of amphetamine that were used in controls, and also interfered with an inhibitory effect of the psychostimulant on the reactions induced by stimulation of the caudate nucleus. It is suggested that the drugs while dopaminergic mechanisms of the neostriatum.
在对猫进行的慢性实验中，记录了尾状核电刺激诱发的停止反应、转圈行为、皮层纺锤波以及阈剂量苯丙胺引发的刻板行为。羟丁酸钠和芬乙茶碱促进运动停止，而γ-羟丁酸钠未表现出这种作用。所有物质均显著降低皮层尾状核诱发纺锤波的阈值。与γ-羟丁酸钠不同，羟丁酸钠和芬乙茶碱在与对照组相同剂量的苯丙胺作用下，减弱了刻板行为，并且还干扰了精神兴奋剂对尾状核刺激所诱发反应的抑制作用。提示这些药物作用于新纹状体的多巴胺能机制。
