Graves S, Downes J
Br J Vener Dis. 1981 Feb;57(1):7-10. doi: 10.1136/sti.57.1.7.
Virulent Treponema paraluis-cuniculi was inoculated intradermally into the arm of a human volunteer and into the shaved backs of 10 rabbits. An identical, but heat-killed, preparation was inoculated into the opposite arm of the volunteer as control. A superficial and transient infection developed in the volunteer, shown by a small zone of erythema that persisted for 24 days. The control preparation caused a smaller zone of erythema that disappeared after five days. A very poor immune response was detected by standard serological tests for syphilis. The inoculated rabbits developed lesions about six days after infection and seroconverted by 84 days. The poor antitreponemal antibody response to T paraluis-cuniculi infection in the volunteer suggests that this naturally attenuated treponeme may not be suitable as a vaccine against infection with t pallidum in humans.
将毒力强的兔梅毒螺旋体皮内接种到一名人类志愿者的手臂以及10只兔子剃毛的背部。将一种相同但经热灭活的制剂作为对照接种到该志愿者的另一只手臂。志愿者出现了浅表性和短暂性感染，表现为持续24天的小面积红斑。对照制剂引起的红斑面积较小，5天后消失。通过梅毒标准血清学检测发现免疫反应非常差。接种的兔子在感染后约6天出现病变，84天时血清转化。志愿者对兔梅毒螺旋体感染的抗梅毒螺旋体抗体反应较差，这表明这种自然减毒的螺旋体可能不适合作为人类抗梅毒感染的疫苗。
