Johnson P, Fromm D
Surgery. 1981 Feb;89(2):206-9.
The hemostatic benefit of bone wax placed in cancellous bone occurs at the expense of the wax persisting at the bony site for years. As such, bone wax appears to act as a foreign body. This study examines the effect of bone wax on the ability of cancellous bone to clear bacteria. The iliac crest of rabbits was penetrated to a standard depth with an 18-gauge needle. Subsequently, nothing or Staphylococcus aureus, 10(5) colony-forming units, was innoculated in the needle site and followed by the subcortical placement of a cylinder of bone wax or similarly sized stainless steel rod. Ten days later, the site of bony penetration was excised and cultured. Eighty percent of animals whose bone was implanted with bacteria and bone wax together had positive cultures. Forty percent of animals whose bone was implanted with bacteria and a steel rod also had positive cultures. The difference between these groups (bacteria with bone wax or with steel rod) was not statistically significant. However, these combinations of bacteria with foreign body were significantly different from the bacteria only or bone wax only or steel rod only groups in which no positive cultures were observed. The data indicate that bone wax significantly impairs the ability of cancellous bone of rabbits to clear a standard inoculum of S. aureus. This effect appears to be the same as that observed with a different but similarly sized foreign body (steel rod).
置于松质骨的骨蜡所带来的止血益处是以骨蜡在骨部位持续数年为代价的。因此，骨蜡似乎起到了异物的作用。本研究考察了骨蜡对松质骨清除细菌能力的影响。用18号针将兔髂嵴穿刺至标准深度。随后，在针穿刺部位接种无物或接种10⁵菌落形成单位的金黄色葡萄球菌，接着在皮质下放置一个骨蜡圆柱体或尺寸相似的不锈钢棒。10天后，切除骨穿刺部位并进行培养。80% 的骨植入细菌和骨蜡的动物培养结果呈阳性。40% 的骨植入细菌和钢棒的动物培养结果也呈阳性。这些组（细菌与骨蜡或与钢棒）之间的差异无统计学意义。然而，这些细菌与异物的组合与仅接种细菌、仅放置骨蜡或仅放置钢棒的组有显著差异，后者未观察到阳性培养结果。数据表明，骨蜡显著损害了兔松质骨清除标准接种量金黄色葡萄球菌的能力。这种效应似乎与用不同但尺寸相似的异物（钢棒）所观察到的效应相同。
