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兔角膜抗真菌药物作用定量测量方法的开发。

Development of quantitative methods of measuring antifungal drug effects in the rabbit cornea.

作者信息

Oji E O

出版信息

Br J Ophthalmol. 1981 Feb;65(2):89-96. doi: 10.1136/bjo.65.2.89.

DOI:10.1136/bjo.65.2.89
PMID:7006679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1039433/
Abstract

By means of multiple inoculation in each cornea with microtrephination a highly reproducible quantitative model of fungal infection of the rabbit corneal stroma has been produced. A known suspension of the chosen pathogen was systematically implanted into the trephine sites in the cornea. The degree of infectivity was monitored in both the preinoculation treated corneae (prophylaxis) and the postinoculation treated corneae (therapy). Examples measuring and comparing the antifungal effect of various imidazole drugs against Candida albicans are discussed.

摘要

通过在每个角膜上进行多次微钻取接种，建立了兔角膜基质真菌感染的高度可重复定量模型。将选定病原体的已知悬液系统地植入角膜的钻取部位。在接种前处理的角膜（预防）和接种后处理的角膜（治疗）中监测感染程度。讨论了测量和比较各种咪唑类药物对白色念珠菌抗真菌作用的实例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/bf585ffa6eeb/brjopthal00182-0029-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/a7688877b1ab/brjopthal00182-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/d61d62d07c7e/brjopthal00182-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/43a8fdfb45d7/brjopthal00182-0027-b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/0dfba1cbb9b0/brjopthal00182-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/bf585ffa6eeb/brjopthal00182-0029-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/a7688877b1ab/brjopthal00182-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/d61d62d07c7e/brjopthal00182-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/43a8fdfb45d7/brjopthal00182-0027-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/fcbbd6828039/brjopthal00182-0027-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/0dfba1cbb9b0/brjopthal00182-0029-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b30/1039433/bf585ffa6eeb/brjopthal00182-0029-b.jpg

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Development of quantitative methods of measuring antifungal drug effects in the rabbit cornea.兔角膜抗真菌药物作用定量测量方法的开发。
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引用本文的文献

1
Mycolase II: an enzyme antifungal agent interacts with the polyene antibiotic pimaricin in the treatment of keratomycosis.霉菌酶II：一种酶类抗真菌剂，在治疗角膜真菌病时与多烯抗生素匹马霉素相互作用。
Int Ophthalmol. 1982 Nov;5(3):175-9. doi: 10.1007/BF00149150.
2
Ketoconazole: a new imidazole antifungal agent has both prophylactic potential and therapeutic efficacy in keratomycosis of rabbits.酮康唑：一种新型咪唑类抗真菌剂对兔角膜真菌病既有预防潜力又有治疗效果。
Int Ophthalmol. 1982 Nov;5(3):163-7. doi: 10.1007/BF00149147.
3
Orally administered antifungal therapy for experimental keratomycosis.

本文引用的文献

1
EXPERIMENTAL CORNEAL HISTOPLASMOSIS.实验性角膜组织胞浆菌病
Br J Ophthalmol. 1964 Jun;48(6):293-7. doi: 10.1136/bjo.48.6.293.
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THERAPEUTIC CONSIDERATIONS IN OCULAR VACCINIA.眼部牛痘的治疗考量
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The use of cortisone in establishing experimental fungal keratitis in rats: a preliminary report.可的松在建立大鼠实验性真菌性角膜炎中的应用：初步报告。
用于实验性角膜真菌病的口服抗真菌治疗
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Am J Ophthalmol. 1959 Sep;48(3), Part 2:330-5.
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Therapy of experimental intraocular Aspergillus infection.
Arch Ophthalmol. 1960 Dec;64:849-61. doi: 10.1001/archopht.1960.01840010851005.
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An animal model of Fusarium solani endophthalmitis.茄病镰刀菌眼内炎动物模型。
Br J Ophthalmol. 1979 Apr;63(4):277-80. doi: 10.1136/bjo.63.4.277.