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犬结肠黏膜浆细胞中的α-内啡肽样免疫反应性

Alpha-endorphin-like immunoreactivity in plasma cells of the canine colonic mucosa.

作者信息

Grube D

出版信息

Histochemistry. 1980;69(2):157-60. doi: 10.1007/BF00533132.

DOI:10.1007/BF00533132
PMID:7007295
Abstract

During immunocytochemical investigations on the presence of opioid peptides in gastrointestinal endocrine cells it was found that a subpopulation of plasma cells located in the lamina propria of the canine colonic mucosa showed immunoreactivities for alpha-endorphin. All immunohistochemical specificity controls proved the specificity of the reaction. Circumstantial evidence suggest, however, that no authentic alpha-endorphin is present within this cell type. Possibly sequence homologies between alpha-endorphin and the amino acid composition of a certain immunoglobulin are responsible for the immunocytochemically specific alpha-endorphin-like immunoreactivity of plasma cells.

摘要

在对胃肠道内分泌细胞中阿片肽存在情况进行免疫细胞化学研究期间，发现位于犬结肠黏膜固有层的浆细胞亚群对α-内啡肽呈免疫反应性。所有免疫组织化学特异性对照均证实了该反应的特异性。然而，间接证据表明，这种细胞类型中不存在真正的α-内啡肽。可能是α-内啡肽与某种免疫球蛋白的氨基酸组成之间的序列同源性导致了浆细胞免疫细胞化学特异性的α-内啡肽样免疫反应性。

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Alpha-endorphin-like immunoreactivity in plasma cells of the canine colonic mucosa.犬结肠黏膜浆细胞中的α-内啡肽样免疫反应性
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引用本文的文献

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A new hypothalamic substance, and not luteinizing hormone-releasing hormone, is detected immunocytochemically by antibody to luteinizing hormone-releasing hormone.一种新的下丘脑物质，而非促黄体生成激素释放激素，通过促黄体生成激素释放激素抗体经免疫细胞化学方法检测出来。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5216-20. doi: 10.1073/pnas.78.8.5216.
2
Evidence for an inhibitory role of beta-endorphin and other opioids on human total T rosette formation.
Experientia. 1984 Jul 15;40(7):738-9. doi: 10.1007/BF01949751.
3
[The endocrine cells of the digestive system (author's transl)].消化系统的内分泌细胞（作者译）

本文引用的文献

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A simple method for removing the resin from epoxy-embedded tissue.一种从环氧树脂包埋组织中去除树脂的简单方法。
J Biophys Biochem Cytol. 1961 Apr;9(4):909-10. doi: 10.1083/jcb.9.4.909.
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Immunoreactivities of gastrin (G-) cells. II. Non-specific binding of immunoglobulins to G-cells by ionic interactions.胃泌素（G-）细胞的免疫反应性。II. 免疫球蛋白通过离子相互作用与G细胞的非特异性结合。
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High-molecular-weight immunoreactive beta-endorphin in extracts of human placenta is a fragment of immunoglobulin G.人胎盘提取物中的高分子量免疫反应性β-内啡肽是免疫球蛋白G的一个片段。
Science. 1980 Apr 11;208(4440):183-5. doi: 10.1126/science.6244620.
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Immunoreactivities of gastrin (G-) cells. I. dilution-dependent staining of G-cells by antisera and non-immune sera.胃泌素（G-）细胞的免疫反应性。I.抗血清和非免疫血清对G细胞的稀释依赖性染色。
Histochemistry. 1980;65(3):223-37. doi: 10.1007/BF00493172.
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Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity.α-内啡肽和γ-内啡肽的分离、一级结构及合成，这两种源于下丘脑 - 垂体且具有吗啡样活性的肽。
Proc Natl Acad Sci U S A. 1976 Nov;73(11):3942-6. doi: 10.1073/pnas.73.11.3942.
7
Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.从骆驼脑垂体中分离出具有阿片样活性的三十一肽并解析其结构。
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1145-8. doi: 10.1073/pnas.73.4.1145.
8
Isolation of peptides with opiate activity from sheep and human pituitaries: relationship to beta-lipotropin.从绵羊和人垂体中分离具有阿片活性的肽：与β-促脂素的关系。
Biochem Biophys Res Commun. 1976 Sep 20;72(2):472-8. doi: 10.1016/s0006-291x(76)80066-6.
9
Complement-mediated unspecific binding of immunoglobulins to some endocrine cells.补体介导的免疫球蛋白与某些内分泌细胞的非特异性结合。
Histochemistry. 1979 Sep;63(1):15-21. doi: 10.1007/BF00508008.
10
Pancreatic glucagon cells contain endorphin-like immunoreactivity.胰腺胰高血糖素细胞含有内啡肽样免疫反应性物质。
Histochemistry. 1978 Dec 28;59(1):75-9. doi: 10.1007/BF00506480.