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Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity.α-内啡肽和γ-内啡肽的分离、一级结构及合成，这两种源于下丘脑 - 垂体且具有吗啡样活性的肽。
Proc Natl Acad Sci U S A. 1976 Nov;73(11):3942-6. doi: 10.1073/pnas.73.11.3942.
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[Endorphins, hypothalamic and neurohypophysial peptides with morphinomimetic activity: isolation and molecular structure of alpha-endorphin].
C R Acad Hebd Seances Acad Sci D. 1976 Feb 23;282(8):783-5.
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Isolation and structure of several peptides from porcine hypothalami.从猪下丘脑分离出几种肽并确定其结构。
Biochim Biophys Acta. 1980 Oct 21;625(2):266-73. doi: 10.1016/0005-2795(80)90290-1.
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Isolation and amino acid sequence of gamma-lipotropin from human pituitary glands.从人垂体中分离γ-促脂素及其氨基酸序列
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7214-7. doi: 10.1073/pnas.77.12.7214.
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Complete amino acid sequence of murine beta 2-microglobulin: structural evidence for strain-related polymorphism.小鼠β2-微球蛋白的完整氨基酸序列：品系相关多态性的结构证据。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):554-8. doi: 10.1073/pnas.78.1.554.
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Isolation and characterization of two peptides with prolactin release-inhibiting activity from porcine hypothalami.从猪下丘脑分离并鉴定出两种具有催乳素释放抑制活性的肽。
Proc Natl Acad Sci U S A. 1991 May 1;88(9):3540-4. doi: 10.1073/pnas.88.9.3540.
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Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor.人下丘脑生长激素释放素（生长激素释放因子）的分离、一级结构及合成
Proc Natl Acad Sci U S A. 1984 Jul;81(14):4302-6. doi: 10.1073/pnas.81.14.4302.
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The human erythrocyte anion-transport protein. Partial amino acid sequence, conformation and a possible molecular mechanism for anion exchange.人类红细胞阴离子转运蛋白。部分氨基酸序列、构象及阴离子交换的一种可能分子机制。
Biochem J. 1983 Sep 1;213(3):577-86. doi: 10.1042/bj2130577.
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Isolation and characterization of hypothalamic growth-hormone releasing factor from common carp, Cyprinus carpio.鲤（Cyprinus carpio）下丘脑生长激素释放因子的分离与特性分析
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Neprilysin inhibition, endorphin dynamics, and early symptomatic improvement in heart failure: a pilot study.中性内肽酶抑制、内啡肽动力学与心力衰竭早期症状改善：一项初步研究。
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An in silico platform for predicting, screening and designing of antihypertensive peptides.用于预测、筛选和设计抗高血压肽的计算机模拟平台。
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Endogenous opioids: opposing stress with a cost.内源性阿片类物质：以付出代价来对抗压力。
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Endogenous Opioids: The Downside of Opposing Stress.内源性阿片类物质：对抗压力的负面影响。
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Extracellular biotransformation of beta-endorphin in rat striatum and cerebrospinal fluid.大鼠纹状体和脑脊液中β-内啡肽的细胞外生物转化
J Neuroendocrinol. 2008 May;20(5):606-16. doi: 10.1111/j.1365-2826.2008.01705.x. Epub 2008 Mar 15.
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Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.含2',6'-二甲基-L-酪氨酸和吡嗪酮环平台的阿片样物质模拟物的设计与合成。
Bioorg Med Chem Lett. 2007 Nov 1;17(21):5768-71. doi: 10.1016/j.bmcl.2007.08.058. Epub 2007 Aug 28.
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Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.3,6-双[H-酪氨酸/H-Dmt-NH(CH2)m,n]-2(1H)吡嗪酮衍生物的合成：烷基链长度对阿片样物质活性的作用
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Isolation and structure of pro-methionine-enkephalin: Potential enkephalin precursor from porcine hypothalamus.促甲硫氨酸脑啡肽的分离与结构：来自猪下丘脑的潜在脑啡肽前体
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6177-80. doi: 10.1073/pnas.76.12.6177.
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Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.哺乳动物枯草杆菌蛋白酶/凯欣同工酶SKI-1：一种广泛表达的前蛋白转化酶，具有独特的切割特异性和细胞定位。
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1321-6. doi: 10.1073/pnas.96.4.1321.
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Alpha-endorphin-like immunoreactivity in plasma cells of the canine colonic mucosa.犬结肠黏膜浆细胞中的α-内啡肽样免疫反应性
Histochemistry. 1980;69(2):157-60. doi: 10.1007/BF00533132.
本文引用的文献
1
[Mass-spectrometric studies, XIV. Effect of aromatic amino acids on electron impulse fragmentation of N-acetyl peptides].[质谱研究，十四。芳香族氨基酸对N-乙酰肽电子脉冲裂解的影响]
Justus Liebigs Ann Chem. 1966 Oct;698:24-33. doi: 10.1002/jlac.19666980104.
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Direct sequence determination of ovine luteinizing hormone releasing factor by mass spectrometry.通过质谱法直接测定绵羊促黄体生成激素释放因子的序列。
Biochemistry. 1973 Dec 18;12(26):5305-10. doi: 10.1021/bi00750a013.
3
Primary structure of the ovine hypothalamic luteinizing hormone-releasing factor (LRF) (LH-hypothalamus-LRF-gas chromatography-mass spectrometry-decapeptide-Edman degradation).绵羊下丘脑促黄体生成激素释放因子（LRF）的一级结构（LH - 下丘脑 - LRF - 气相色谱 - 质谱法 - 十肽 - 埃德曼降解法）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):278-82. doi: 10.1073/pnas.69.1.278.
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Synthesis of a pentekontapeptide with high lipolytic activity corresponding to the carboxyl-terminal fifty amino acids of ovine beta-lipotropin.与绵羊β-促脂素羧基末端五十个氨基酸相对应的具有高脂肪分解活性的五十肽的合成。
Proc Natl Acad Sci U S A. 1974 Dec;71(12):4945-9. doi: 10.1073/pnas.71.12.4945.
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Primary structure of somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone.生长抑素的一级结构，一种抑制垂体生长激素分泌的下丘脑肽。
Proc Natl Acad Sci U S A. 1973 Mar;70(3):684-8. doi: 10.1073/pnas.70.3.684.
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The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips.豚鼠肠道和纵肌条释放的乙酰胆碱的来源。
J Physiol. 1968 Jan;194(1):13-33. doi: 10.1113/jphysiol.1968.sp008392.
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C fragment of lipotropin has a high affinity for brain opiate receptors.促脂解素的C片段对脑阿片受体具有高亲和力。
Nature. 1976 Apr 29;260(5554):793-5. doi: 10.1038/260793a0.
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Identification of two related pentapeptides from the brain with potent opiate agonist activity.从大脑中鉴定出两种具有强效阿片激动剂活性的相关五肽。
Nature. 1975 Dec 18;258(5536):577-80. doi: 10.1038/258577a0.
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A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties.1. 一种来自垂体的、作用类似吗啡的肽样物质。2. 纯化及特性。
Life Sci. 1975 Jun 15;16(12):1777-82. doi: 10.1016/0024-3205(75)90272-6.
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An endogenous morphine-like factor in mammalian brain.哺乳动物大脑中的一种内源性类吗啡因子。
Life Sci. 1975 Jun 15;16(12):1765-9. doi: 10.1016/0024-3205(75)90270-2.
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