Grossman J A, Adams J P, Kunec J
JAMA. 1981 Mar 13;245(10):1055-6.
A randomized prospective study of 265 patients with hand lacerations was carried out to define the role of prophylactic antibiotics in the management of simple, sutured wounds of the hand. Two hundred sixty-five patients were followed up until suture removal or satisfactory wound healing. There were a total of three infections (1.1%). There was no noticeable differences in the incidence of infection in the antibiotic and placebo treatment groups. It is concluded that prophylactic antibiotics are an unnecessary adjunct in the treatment of simple lacerations of the hand and no replacement for meticulous wound management.
对265例手部裂伤患者进行了一项随机前瞻性研究，以确定预防性抗生素在手部单纯缝合伤口处理中的作用。265例患者随访至缝线拆除或伤口愈合良好。共有3例感染（1.1%）。抗生素治疗组和安慰剂治疗组的感染发生率无明显差异。结论是预防性抗生素在手部单纯裂伤治疗中是不必要的辅助手段，不能替代细致的伤口处理。
