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微型染色体复制的功能分析：来自大肠杆菌复制起点oriC的双向和单向复制

Functional analysis of minichromosome replication: bidirectional and unidirectional replication from the Escherichia coli replication origin, oriC.

作者信息

Meijer M, Messer W

出版信息

J Bacteriol. 1980 Aug;143(2):1049-53. doi: 10.1128/jb.143.2.1049-1053.1980.

DOI:10.1128/jb.143.2.1049-1053.1980
PMID:7009545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC294416/
Abstract

Replicating molecules of minichromosomes pCM959 and pOC24 were analyzed by electron microscopy. Replication of pCM959 proceeded bidirectionally from the replication origin, oriC, in about 60% of the molecules; the rest of the molecules replicated unidirectionally in either direction. pOC24, in which deoxyribonucleic acid to the right (clockwise) of the oriC segment is deleted, seemed to replicate predominantly unidirectionally counterclockwise from oriC.

摘要

通过电子显微镜对微型染色体pCM959和pOC24的复制分子进行了分析。在大约60%的分子中，pCM959从复制起点oriC开始双向复制；其余分子则沿任一方向单向复制。pOC24中oriC片段右侧（顺时针方向）的脱氧核糖核酸被删除，它似乎主要从oriC开始逆时针单向复制。

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Functional analysis of minichromosome replication: bidirectional and unidirectional replication from the Escherichia coli replication origin, oriC.微型染色体复制的功能分析：来自大肠杆菌复制起点oriC的双向和单向复制
J Bacteriol. 1980 Aug;143(2):1049-53. doi: 10.1128/jb.143.2.1049-1053.1980.
2
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本文引用的文献

1
Replication origin of the Escherichia coli K-12 chromosome: the size and structure of the minimum DNA segment carrying the information for autonomous replication.大肠杆菌K-12染色体的复制起点：携带自主复制信息的最小DNA片段的大小和结构
Mol Gen Genet. 1980 Apr;178(1):9-20. doi: 10.1007/BF00267207.
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A DNA-binding protein specific for the early replicated region of the chromosome obtained from Escherichia coli membrane fractions.一种从大肠杆菌膜组分中获得的、对染色体早期复制区域具有特异性的DNA结合蛋白。
Eur J Biochem. 1980 Mar;105(1):25-31. doi: 10.1111/j.1432-1033.1980.tb04470.x.
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Position of branch points in replicating lambda DNA.复制型λ噬菌体DNA中分支点的位置
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Evidence for the bidirectional replications of the Escherichia coli chromosome.大肠杆菌染色体双向复制的证据。
Nat New Biol. 1971 Aug 4;232(31):137-40. doi: 10.1038/newbio232137a0.
5
Origin and sequence of chromosome replication in Escherichia coli.大肠杆菌中染色体复制的起源与顺序
J Mol Biol. 1972 Oct 14;70(3):549-66. doi: 10.1016/0022-2836(72)90559-1.
6
Bidirectional replication of the chromosome in Escherichia coli.大肠杆菌中染色体的双向复制。
Proc Natl Acad Sci U S A. 1972 Oct;69(10):2842-5. doi: 10.1073/pnas.69.10.2842.
7
RNA synthesis startpoints in bacteriophage lambda: are the promoter and operator transcribed?噬菌体λ中的RNA合成起始点：启动子和操纵基因会被转录吗？
Nat New Biol. 1972 Jun 21;237(77):227-32. doi: 10.1038/newbio237227a0.
8
Novel F prime factors able to replicate in Escherichia coli Hfr strains.能够在大肠杆菌高频重组（Hfr）菌株中复制的新型F'因子。
Proc Natl Acad Sci U S A. 1976 Jan;73(1):198-202. doi: 10.1073/pnas.73.1.198.
9
Effect of thymine concentration on the mode of chromosomal replication in Escherichia coli K-12.胸腺嘧啶浓度对大肠杆菌K-12染色体复制模式的影响。
J Mol Biol. 1976 Dec;108(2):295-303. doi: 10.1016/s0022-2836(76)80122-2.
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Recalibrated linkage map of Escherichia coli K-12.大肠杆菌K-12的重新校准连锁图谱。
Bacteriol Rev. 1976 Mar;40(1):116-67. doi: 10.1128/br.40.1.116-167.1976.