胎兔和新生兔肺中前列环素（PGI2）的生成

Prostacyclin (PGI2) generation in lungs of fetal and newborn rabbit.

作者信息

Omini C, Brunelli G, Folco G C, Marini A, Pasargiklian R, Berti F

出版信息

Prostaglandins. 1981 Feb;21(2):345-51. doi: 10.1016/0090-6980(81)90152-0.

Abstract

Perfused lungs from fetal (26-28 days of gestation) and newborn rabbits preferentially transform arachidonic acid into a substance which mimics PGI2 activity on different isolated tissues in cascase. These data support the hypothesis that antiplatelet and vasodilating vasodilating activity of PGI2 generated in the lungs may contribute to the characteristics of the fetal circulation.

摘要

来自胎兔（妊娠26 - 28天）和新生兔的灌注肺优先将花生四烯酸转化为一种物质，该物质在体外实验中对不同离体组织具有类似前列环素（PGI2）的活性。这些数据支持以下假说：肺中产生的PGI2的抗血小板和血管舒张活性可能有助于胎儿循环的特征。