Gilbert P, Fabry L, Rollmann B, Lombart P, Rondelet J, Poncelet F, Leonard A, Mercier M
Mutat Res. 1981 Jul;89(3):217-28. doi: 10.1016/0165-1218(81)90240-8.
The mutagenicity of N-nitrosodiethanolamine and its mono- and di-acetyl derivatives was tested in the S. typhimurium test system, in cytogenetic studies and in the micronucleus test. N-nitrosodiethanolamine had no mutagenic effects towards several strains of S. typhimurium either in the absence or in the presence of metabolic activating systems. Its diacetyl derivative exerted mutagenic effects towards the S. typhimurium strains TA1530 and TA100. Neither compound increased significantly the nubmer of chromosomal aberrations or of micronuclei in mice.
在鼠伤寒沙门氏菌测试系统、细胞遗传学研究和微核试验中对N-亚硝基二乙醇胺及其单乙酰和二乙酰衍生物的致突变性进行了测试。N-亚硝基二乙醇胺无论在有无代谢激活系统的情况下，对几种鼠伤寒沙门氏菌菌株均无致突变作用。其二乙酰衍生物对鼠伤寒沙门氏菌菌株TA1530和TA100有致突变作用。两种化合物均未显著增加小鼠染色体畸变或微核的数量。
