Srinivasan V, Christensen N, Wyse B W, Hansen R G
Am J Clin Nutr. 1981 Sep;34(9):1736-42. doi: 10.1093/ajcn/34.9.1736.
Pantothenic acid nutritional status was evaluated in 37 men (32 noninstitutionalized and five institutionalized) and 54 women (33 noninstitutionalized and 21 institutionalized) 65 yr of age or older. A fasting blood sample, a 24-h urine specimen and a food consumption record for 1 wk were obtained from each subject. Hematological, anthropometric, and dietary parameters indicated these 91 subjects were similar to elderly populations evaluated in other studies. Pantothenic acid was analyzed by both radioimmunoassay and microbiological assay. By combining methods it was possible to differentiate various forms and derivatives of pantothenic acid. Free pantothenic acid, but not the phosphoderivatives, was observed in urine. Microbiological and radioimmunoassay estimations of pantothenic acid showed good correlation (r = 0.91). Pantothenic acid excretion in the institutionalized subjects (7.5 +/- 1.3 (x +/- SEM) mg/g creatinine) was comparable to the excretion levels in the noninstitutionalized subjects (5.9 +/- 0.6 mg/g creatinine). Those consuming pantothenic acid supplements had significantly higher excretion levels. Blood pantothenic acid values between the groups, noninstitutionalized (537 +/- 27.4 ng/ml) and institutionalized (615 +/- 47.3 ng/ml), were comparable. The average dietary intake of pantothenic acid for the elderly population studied was 5.9 +/- 0.1 mg/day with the institutionalized and noninstitutionalized subjects having a similar intake of 2.9 mg/1000 kcal. Institutionalized elderly males and females were consuming 2237 and 1962 kcal, respectively, while their noninstitutionalized counterparts were consuming 2201 and 1887 kcal.
对37名65岁及以上男性（32名非机构养老者和5名机构养老者）和54名65岁及以上女性（33名非机构养老者和21名机构养老者）的泛酸营养状况进行了评估。从每位受试者处采集了一份空腹血样、一份24小时尿液标本以及一份为期1周的食物摄入记录。血液学、人体测量学和饮食参数表明，这91名受试者与其他研究中评估的老年人群相似。通过放射免疫测定法和微生物测定法对泛酸进行了分析。通过结合这两种方法，可以区分泛酸的各种形式和衍生物。在尿液中观察到了游离泛酸，但未观察到磷酸衍生物。微生物测定法和放射免疫测定法对泛酸的估计显示出良好的相关性（r = 0.91）。机构养老受试者的泛酸排泄量（7.5±1.3（x±标准误）mg/g肌酐）与非机构养老受试者的排泄水平（5.9±0.6 mg/g肌酐）相当。服用泛酸补充剂的受试者排泄水平显著更高。非机构养老组（537±27.4 ng/ml）和机构养老组（615±47.3 ng/ml）之间的血液泛酸值相当。所研究老年人群的泛酸平均膳食摄入量为5.9±0.1 mg/天，机构养老和非机构养老受试者的摄入量相似，均为2.9 mg/1000千卡。机构养老的老年男性和女性分别摄入2237千卡和1962千卡，而非机构养老的老年男性和女性分别摄入2201千卡和1887千卡。
