Stimson W H
Clin Exp Immunol. 1977 Jun;28(3):445-52.
Pregnancy-associated alpha-macroglobulin (PAM) was identified on the surface membranes of human peripheral blood leucocytes by immunofluorescent staining. Subjects having a high serum-level of the glycoprotein (pregnant and contraceptive steroid-treated women) were shown to possess a significantly greater proportion of PAM-positive cells than those (normal males) with a low concentration. However, no correlation was found between the serum values and the percentage of PAM-associated leucocytes. Studies employing purified leucocyte-types and the simultaneous detection of PAM and lymphocyte surface markers indicated that only subpopulations of T lymphocytes (23%) and monocytes (40%) were associated with this serum protein.
通过免疫荧光染色在人外周血白细胞的表面膜上鉴定出妊娠相关α-巨球蛋白（PAM）。结果显示，与糖蛋白血清水平高的受试者（孕妇和接受避孕类固醇治疗的女性）相比，糖蛋白浓度低的受试者（正常男性）拥有PAM阳性细胞的比例明显更高。然而，未发现血清值与PAM相关白细胞百分比之间存在相关性。使用纯化白细胞类型以及同时检测PAM和淋巴细胞表面标志物的研究表明，只有T淋巴细胞亚群（23%）和单核细胞亚群（40%）与这种血清蛋白相关。
