Hill S L, Elings V B, Lewis F
Am Surg. 1981 Dec;47(12):522-8.
Extravascular lung water (EVLW) and cardiac output (CO) were determined in 21 mongrel dogs using the thermal-green dye double indicator dilution technique. In 12 of the animals the renal vessels were ligated bilaterally to increase peripheral resistance and reduce cardiac output without altering actual EVLW. Measurements before and after renal pedicle ligation revealed an average 47 per cent decrease in cardiac output with an 11 per cent increase in measured lung water. In the remaining nine animals an external arteriovenous fistula was constructed to reduce afterload and increase cardiac output. In the baseline state, opening the fistula caused a 63 per cent increase in cardiac output with a simultaneous five per cent decrease in measured EVLW. This second group of animals was then given intravenous acid sufficient to cause 30-50 per cent increases in EVLW. Measurements of EVLW and CO with the fistula open and closed were continued for three hours. The inverse relation between cardiac output and EVLW continued. The results of these experiments show that cardiac output does exert a small effect on the measurement of EVLW.
采用热绿染料双指示剂稀释技术测定了21只杂种犬的血管外肺水（EVLW）和心输出量（CO）。在12只动物中，双侧结扎肾血管以增加外周阻力并降低心输出量，而不改变实际的血管外肺水。肾蒂结扎前后的测量结果显示，心输出量平均下降47%，而测量的肺水量增加11%。在其余9只动物中，构建了体外动静脉瘘以降低后负荷并增加心输出量。在基线状态下，开放瘘管使心输出量增加63%，同时测量的血管外肺水下降5%。然后给这第二组动物静脉注射酸，足以使血管外肺水增加30% - 50%。在瘘管开放和关闭的情况下，持续测量血管外肺水和心输出量3小时。心输出量与血管外肺水之间的反比关系依然存在。这些实验结果表明，心输出量确实对血管外肺水的测量有微小影响。
