Barros Luiz Marivando, Duarte Antonia Eliene, Morais-Braga Maria Flaviana Bezerra, Waczuk Emily Pansera, Vega Celeste, Leite Nadghia Figueiredo, de Menezes Irwin Rose Alencar, Coutinho Henrique Douglas Melo, Rocha João Batista Teixeira, Kamdem Jean Paul
Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil.
Post-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, Brazil.
Molecules. 2016 Feb 10;21(2):209. doi: 10.3390/molecules21020209.
Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. In this context, the essential oil extracted by hydro-distillation from Lantana camara leaves was tested against Leishmania braziliensis and Trypanosoma cruzi. The results demonstrated that L. camara essential oil inhibited T. cruzi and L. braziliensis with IC50 of 201.94 μg/mL and 72.31 μg/mL, respectively. L. camara essential oil was found to be toxic to NCTC929 fibroblasts at 500 μg/mL (IC50 = 301.42 μg/mL). The composition of L. camara essential oil analyzed by gas chromatography-mass spectrometry (GC/MS) revealed large amounts of (E)-caryophyllene (23.75%), biciclogermacrene (15.80%), germacrene D (11.73%), terpinolene (6.1%), and sabinene (5.92%), which might be, at least in part, responsible for its activity. Taken together, our results suggest that L. camara essential oil may be an important source of therapeutic agents for the development of alternative drugs against parasitic diseases.
在治疗利什曼病和锥虫病等被忽视的寄生虫病时，耐药性问题促使人们从植物中寻找和开发替代药物。在此背景下，对通过水蒸馏法从马缨丹叶片中提取的精油进行了抗巴西利什曼原虫和克氏锥虫的测试。结果表明，马缨丹精油对克氏锥虫和巴西利什曼原虫具有抑制作用，其IC50分别为201.94μg/mL和72.31μg/mL。发现马缨丹精油在500μg/mL时对NCTC929成纤维细胞有毒性（IC50 = 301.42μg/mL）。通过气相色谱-质谱联用（GC/MS）分析的马缨丹精油成分显示，含有大量的（E）-石竹烯（23.75%）、双环吉玛烯（15.80%）、吉玛烯D（11.73%）、萜品油烯（6.1%）和桧烯（5.92%），这些成分可能至少部分地解释了其活性。综上所述，我们的结果表明，马缨丹精油可能是开发抗寄生虫病替代药物治疗剂的重要来源。
