与多聚（DL-丙氨酸）-聚（L-赖氨酸）载体偶联后，胞壁酰二肽衍生物某些生物活性的增强。
Enhancement of certain biological activities of muramyl dipeptide derivatives after conjugation to a multi-poly(DL-alanine)--poly(L-lysine) carrier.
作者信息
Chedid L, Parant M, Parant F, Audibert F, Lefrancier F, Choay J, Sela M
出版信息
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6557-61. doi: 10.1073/pnas.76.12.6557.
Abstract
N-Acetylmuramyl-L-Ala-D-Glu-NH2 (muramyl dipeptide) and several of its derivatives are effective immunoactivators that can enhance nonspecific resistance to infection but can also elicit fever. In contrast, one of its stereoisomers, N-acetylmuramyl-D-Ala-D-Glu-NH2, is devoid of both these activities. Our present report demonstrates that macromolecularization of muramyl dipeptide by attachment of several units to a multi-poly(DL-Ala)-poly(L-Lys) carrier potentiates both its pyrogenic and its immunostimulant activity. This branched polymer has been extensively used as carrier to various haptens. Surprisingly, inactive N-acetylmuramyl-D-Ala-D-Glu-NH2, after conjugation under the same conditions, becomes capable of increasing nonspecific immunity although its lack of pyrogenicity is not greatly modified. Moreover, the N-acetylmuramyl-D-Ala-D-Glu--NH2 conjugate remains devoid of adjuvant, sensitizing, or eliciting activity.
摘要
N-乙酰胞壁酰-L-丙氨酸-D-谷氨酸-NH2（胞壁酰二肽）及其几种衍生物是有效的免疫激活剂，它们既能增强对感染的非特异性抵抗力，也能引起发热。相比之下，其一种立体异构体N-乙酰胞壁酰-D-丙氨酸-D-谷氨酸-NH2则既无上述两种活性。我们目前的报告表明，通过将几个单元连接到多聚（DL-丙氨酸）-聚（L-赖氨酸）载体上使胞壁酰二肽大分子化，可增强其致热活性和免疫刺激活性。这种支链聚合物已被广泛用作各种半抗原的载体。令人惊讶的是，无活性的N-乙酰胞壁酰-D-丙氨酸-D-谷氨酸-NH2在相同条件下共轭后，虽然其无致热原性没有太大改变，但却能够增强非特异性免疫力。此外，N-乙酰胞壁酰-D-丙氨酸-D-谷氨酸-NH2共轭物仍然没有佐剂、致敏或激发活性。
相似文献
1
Enhancement of certain biological activities of muramyl dipeptide derivatives after conjugation to a multi-poly(DL-alanine)--poly(L-lysine) carrier.与多聚（DL-丙氨酸）-聚（L-赖氨酸）载体偶联后，胞壁酰二肽衍生物某些生物活性的增强。
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6557-61. doi: 10.1073/pnas.76.12.6557.
2
Biological activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity.一种无致热原性的新型合成胞壁酰肽佐剂的生物活性。
Infect Immun. 1982 Feb;35(2):417-24. doi: 10.1128/iai.35.2.417-424.1982.
3
Immunostimulant activities of a lipophilic muramyl dipeptide derivative and of desmuramyl peptidolipid analogs.一种亲脂性胞壁酰二肽衍生物和去胞壁酰肽脂类似物的免疫刺激活性。
Infect Immun. 1980 Mar;27(3):826-31. doi: 10.1128/iai.27.3.826-831.1980.
4
Macrophage stimulation in vitro by an inactive muramyl dipeptide derivative after conjugation to a multi-poly(DL-alanyl)-poly(L-lysine) carrier.与多聚（DL-丙氨酰）-聚（L-赖氨酸）载体偶联后，一种无活性的胞壁酰二肽衍生物在体外对巨噬细胞的刺激作用。
Infect Immun. 1980 Apr;28(1):1-5. doi: 10.1128/iai.28.1.1-5.1980.
5
Enhancement of the neonate's nonspecific immunity to Klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant.合成免疫佐剂胞壁酰二肽增强新生儿对克雷伯菌感染的非特异性免疫力。
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3395-9. doi: 10.1073/pnas.75.7.3395.
6
Immunoadjuvant effects of the synthetic muramyl-dipeptide (MDP) N-acetylmuramyl-L-alanyl-D-isoglutamine.合成的胞壁酰二肽（MDP）N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺的免疫佐剂作用。
Z Immunitatsforsch Immunobiol. 1978 Oct;155(1):87-92.
7
Adjuvant activity of 6-O-mycoloyl derivatives of N-acetylmuramyl-L-seryl-D-isoglutamine and related compounds in mice and guinea pigs.N-乙酰胞壁酰-L-丝氨酰-D-异谷氨酰胺的6-O-霉菌酰衍生物及相关化合物在小鼠和豚鼠中的佐剂活性
Infect Immun. 1979 Apr;24(1):83-9. doi: 10.1128/iai.24.1.83-89.1979.
8
Stimulation of nonspecific host resistance to infection induced by muramyldipeptides.胞壁酰二肽诱导的非特异性宿主抗感染抵抗力的刺激作用。
Microbiol Immunol. 1981;25(10):1047-58. doi: 10.1111/j.1348-0421.1981.tb00111.x.
9
Fate of two 14C labelled muramyl peptides: Ac-Mur-L-Ala-gamma-D-Glu-meso-A2pm and Ac-Mur-L-Ala-gamma-D-Glu-meso-A2pm-D-Ala-D-Ala in mice. Evaluation of their ability to increase non specific resistance to Klebsiella infection.两种14C标记的胞壁酰肽的命运：N-乙酰胞壁酰-L-丙氨酸-γ-D-谷氨酸-meso-二氨基庚二酸和N-乙酰胞壁酰-L-丙氨酸-γ-D-谷氨酸-meso-二氨基庚二酸-D-丙氨酸-D-丙氨酸在小鼠体内的情况。对它们增强对克雷伯菌感染的非特异性抵抗力能力的评估。
Int J Immunopharmacol. 1982;4(3):143-9. doi: 10.1016/0192-0561(82)90042-x.
10
Effect of L18-MDP(Ala), a synthetic derivative of muramyl dipeptide, on nonspecific resistance of mice to microbial infections.胞壁酰二肽的合成衍生物L18-MDP（丙氨酸）对小鼠抗微生物感染非特异性抵抗力的影响。
Infect Immun. 1982 Jul;37(1):292-300. doi: 10.1128/iai.37.1.292-300.1982.
引用本文的文献
1
Peptides and proteins as drugs.肽类和蛋白质类药物。
Pharm Res. 1985 Jul;2(4):151-6. doi: 10.1023/A:1016327803573.
2
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.胞壁酰二肽激活核苷酸结合寡聚化结构域2可保护小鼠免受实验性结肠炎的侵害。
J Clin Invest. 2008 Feb;118(2):545-59. doi: 10.1172/JCI33145.
3
Pericholangitis in a rabbit colitis model induced by injection of muramyl dipeptide emulsified with a long-chain fatty acid.通过注射用长链脂肪酸乳化的胞壁酰二肽诱导的兔结肠炎模型中的胆管周围炎。
J Gastroenterol. 1996 Jun;31(3):347-52. doi: 10.1007/BF02355023.
4
Extraintestinal manifestations of granulomatous enterocolitis induced in rabbits by long-term submucosal administration of muramyl dipeptide emulsified with Freund's incomplete adjuvant.长期经黏膜下给予用弗氏不完全佐剂乳化的胞壁酰二肽诱导兔产生肉芽肿性小肠结肠炎的肠外表现。
J Gastroenterol. 1996 Apr;31(2):199-206. doi: 10.1007/BF02389518.
5
Effects of treatment with muramyl dipeptide and certain of its analogs on resistance to Listeria monocytogenes in mice.用胞壁酰二肽及其某些类似物治疗对小鼠抗单核细胞增生李斯特菌能力的影响。
Infect Immun. 1980 Nov;30(2):462-6. doi: 10.1128/iai.30.2.462-466.1980.
6
Immunostimulant activities of a lipophilic muramyl dipeptide derivative and of desmuramyl peptidolipid analogs.一种亲脂性胞壁酰二肽衍生物和去胞壁酰肽脂类似物的免疫刺激活性。
Infect Immun. 1980 Mar;27(3):826-31. doi: 10.1128/iai.27.3.826-831.1980.
7
Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice.胞壁酰二肽类似物对小鼠铜绿假单胞菌或白色念珠菌感染的保护作用。
Infect Immun. 1981 Dec;34(3):676-83. doi: 10.1128/iai.34.3.676-683.1981.
8
Effects of muramyl dipeptide treatment on resistance to infection with Toxoplasma gondii in mice.胞壁酰二肽处理对小鼠抗弓形虫感染能力的影响。
Infect Immun. 1981 Feb;31(2):716-22. doi: 10.1128/iai.31.2.716-722.1981.
9
Muramyl peptides. Chemical structure, biological activity and mechanism of action.胞壁酰肽。化学结构、生物活性及作用机制。
Mol Cell Biochem. 1981 Dec 4;41:27-47. doi: 10.1007/BF00225295.
10
Successful immunization with a totally synthetic diphtheria vaccine.用完全合成的白喉疫苗成功免疫。
Proc Natl Acad Sci U S A. 1982 Aug;79(16):5042-6. doi: 10.1073/pnas.79.16.5042.
本文引用的文献
1
Studies on the types of immune responses to synthetic antigens in guinea-pigs.豚鼠对合成抗原免疫反应类型的研究。
Immunology. 1966 Dec;11(6):561-70.
2
Role of optical configuration in the immunogenicity and specificity of synthetic antigens derived from multichain polyproline.光学构型在源自多链聚脯氨酸的合成抗原的免疫原性和特异性中的作用
J Biol Chem. 1968 Nov 10;243(21):5616-26.
3
Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.细菌肽聚糖衍生物佐剂活性的最小结构要求。
Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317-25. doi: 10.1016/0006-291x(74)90458-6.
4
Immunoadjuvant activities of synthetic N-acetyl-muramyl-peptides or -amino acids.合成的N-乙酰胞壁酰肽或氨基酸的免疫佐剂活性。
Biken J. 1975 Jun;18(2):105-11.
5
6
Modulation of the immune response by a synthetic adjuvant and analogs.一种合成佐剂及其类似物对免疫反应的调节作用。
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2472-5. doi: 10.1073/pnas.73.7.2472.
7
Fate of the synthetic immunoadjuvant, muramyl dipeptide (14C-labelled) in the mouse.合成免疫佐剂胞壁酰二肽（14C标记）在小鼠体内的命运
Int J Immunopharmacol. 1979;1(1):35-41. doi: 10.1016/0192-0561(79)90028-6.
8
9
Enhancement of the neonate's nonspecific immunity to Klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant.合成免疫佐剂胞壁酰二肽增强新生儿对克雷伯菌感染的非特异性免疫力。
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3395-9. doi: 10.1073/pnas.75.7.3395.
10
Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs.一种合成免疫佐剂（N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺）及其几种类似物增强对肺炎克雷伯菌感染的非特异性免疫力。
Proc Natl Acad Sci U S A. 1977 May;74(5):2089-93. doi: 10.1073/pnas.74.5.2089.
Zotero 插件