Ringsdorf W M, Cheraskin E
Oral Surg Oral Med Oral Pathol. 1982 Mar;53(3):231-6. doi: 10.1016/0030-4220(82)90295-x.
Clinical studies provide evidence that wound healing in subjects judged not deficient in vitamin C can be significantly accelerated with supplements of this nutrient above the recommended daily allowance (RDA). The authors administered daily dosages of 500 to 3,000 mg., which is roughly 8 to 50 times the RDA of 60 mg., to subjects recovering from surgery, other injuries, decubital ulcers, and leg ulcers induced by hemolytic anemia. Genetic impairment of collagen synthesis has also been observed to be responsive to ascorbic acid supplementation in an 8-year-old boy with Type VI Ehlers-Danlos syndrome. Four grams of ascorbic acid daily produced a significant improvement in the quality of newly synthesized collagen but did not alter that formed prior to the supplementation of C. The combined evidence in this review provides a substantial base for further research, both clinical and experimental trials, concerning the interrelationships between vitamin C and the body's healing potential.
临床研究表明，对于判定并不缺乏维生素C的受试者，补充超出推荐每日摄入量（RDA）的这种营养素，伤口愈合速度可显著加快。作者给那些正在从手术、其他损伤、褥疮以及溶血性贫血引起的腿部溃疡中恢复的受试者，每日服用500至3000毫克的剂量，这大约是60毫克RDA的8至50倍。在一名患有VI型埃勒斯-当洛综合征的8岁男孩中，也观察到胶原合成的基因损伤对抗坏血酸补充有反应。每日4克抗坏血酸使新合成的胶原蛋白质量有显著改善，但并未改变补充维生素C之前形成的胶原蛋白质量。本综述中的综合证据为进一步开展临床和实验性研究提供了坚实基础，这些研究旨在探究维生素C与人体愈合潜能之间的相互关系。
