Pisalsitsakul Nanthanut, Pinnoi Chaiwat, Sutanthavibul Narueporn, Kamolratanakul Paksinee
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Int J Dent. 2022 Mar 10;2022:6437200. doi: 10.1155/2022/6437200. eCollection 2022.
Vitamin C is essential for wound healing. However, there are no reports concerning the effect of a different dose of vitamin C on extraction wound size clinically. Therefore, the aim of this study was to investigate the effect of different oral vitamin C doses on extraction wound healing. A split-mouth, double-blind randomized clinical trial was performed in 42 patients who underwent symmetric bilateral noninfected premolar extraction. The patients were randomly divided into 3 groups, namely, P/600, P/1,500, and 600/1,500 (14 patients for each group); P/600: placebo vs. 600 mg vitamin C/d, P/1,500: placebo vs. 1,500 mg vitamin C/d, and 600/1,500: 600 mg vitamin C/d vs. 1,500 mg vitamin C/d. Patients were prescribed placebo or/and vitamin C three times a day for 10 days after each tooth extraction. Extraction wound size and pain score were evaluated. The wound assessment was performed on day 0, 7, and 21; and then the tooth on the other side was extracted using the same protocol. Pain score was recorded on the first three days after extraction. The reduced size of mesiodistal extraction wound in percentage reduction between day 0 and 7 of teeth receiving vitamin C 600 mg/d was more than that in placebo ( < 0.05). Pain scores on day 1-3 of teeth receiving vitamin C 600 mg/d were significantly lower than the placebo side ( < 0.05). Taking oral vitamin C 600 mg/d over three doses for 10 days after tooth extraction enhances extraction wound healing by reducing mesiodistal extraction wound and reduces postoperative pain.
维生素C对伤口愈合至关重要。然而，临床上尚无关于不同剂量维生素C对拔牙创大小影响的报道。因此，本研究的目的是探讨不同口服维生素C剂量对拔牙创愈合的影响。对42例行双侧对称非感染前磨牙拔除术的患者进行了一项双侧对照、双盲随机临床试验。患者被随机分为3组，即P/600组、P/1500组和600/1500组（每组14例）；P/600组：安慰剂对照 vs. 维生素C 600毫克/天，P/1500组：安慰剂对照 vs. 维生素C 1500毫克/天，600/1500组：维生素C 600毫克/天 vs. 维生素C 1500毫克/天。每次拔牙后，患者每天服用3次安慰剂或/和维生素C，共10天。评估拔牙创大小和疼痛评分。在第0、7和21天进行创口评估；然后用相同方案拔除另一侧牙齿。在拔牙后的前三天记录疼痛评分。接受600毫克/天维生素C治疗的牙齿在第0天至第7天近远中拔牙创缩小的百分比大于安慰剂组（P<0.05）。接受600毫克/天维生素C治疗的牙齿在第1 - 3天的疼痛评分显著低于安慰剂组（P<0.05）。拔牙后连续10天每天分三次口服600毫克维生素C可通过减小近远中拔牙创促进拔牙创愈合并减轻术后疼痛。
