Goodman D R, James R C, Harbison R D
Food Chem Toxicol. 1982 Feb;20(1):123-8. doi: 10.1016/s0278-6915(82)80018-5.
A review is presented of the literature concerning the placenta as a target organ for chemical- and drug-induced injuries that can ultimately lead to teratogenesis or reproductive defects. Such defects can result from the effects of xenobiotics on placental transport, blood flow or pathology, from the metabolism by the placenta of xenobiotics to harmful substances, or from the alteration by xenobiotics of placental endocrine function. Although it is clear that drug- or chemical-induced placental toxicity should be considered as a possible mechanism of teratogenicity, it is an area of research that has been comparatively neglected and is in need of extensive investigation.
本文综述了有关胎盘作为化学物质和药物诱导损伤的靶器官的文献，这些损伤最终可能导致致畸或生殖缺陷。此类缺陷可能源于外源化学物对胎盘转运、血流或病理的影响，源于胎盘将外源化学物代谢为有害物质，或源于外源化学物对胎盘内分泌功能的改变。虽然药物或化学物诱导的胎盘毒性应被视为致畸性的一种可能机制这一点很明确，但它是一个相对被忽视的研究领域，需要进行广泛的调查。
