Taplin D, Castillero P M, Spiegel J, Mercer S, Rivera A A, Schachner L
JAMA. 1982 Jun 11;247(22):3103-5.
One hundred fifteen subjects took part in a double-blind study comparing the efficacy and safety of 0.5% malathion lotion (Prioderm lotion) and the alcoholic vehicle of the lotion as pediculicides in the treatment of head lice. The subjects, with a mean age of 9 years, had long-standing lice infestations and at least 20 viable ova. The subjects were treated with the test preparation, which was allowed to remain on the hair for 12 hours. Ovicidal and pediculicidal efficacy for the malathion lotion was significant; overall clinical evaluation by the investigators showed a significant number of moderate to marked therapeutic responses to malathion lotion. Only one adverse reaction (in the malathion lotion group) was reported, the stinging of pyodermal lesions in reaction to the alcoholic vehicle. Other concomitant scalp diseases were unchanged or improved at the end of the study.
115名受试者参与了一项双盲研究，该研究比较了0.5%马拉硫磷洗剂（Prioderm洗剂）及其酒精赋形剂作为杀虱剂治疗头虱的疗效和安全性。受试者的平均年龄为9岁，长期受虱子侵扰且至少有20个活卵。受试者接受了试验制剂治疗，该制剂在头发上保留12小时。马拉硫磷洗剂的杀卵和杀虱效果显著；研究人员的总体临床评估显示，对马拉硫磷洗剂有大量中度至显著的治疗反应。仅报告了1例不良反应（在马拉硫磷洗剂组），即酒精赋形剂引起的脓疱性皮损刺痛。在研究结束时，其他伴随的头皮疾病未改变或有所改善。
