Coutinho S G, Leite M A, Amendoeira M R, Marzochi M C
J Infect Dis. 1982 Jul;146(1):30-3. doi: 10.1093/infdis/146.1.30.
During 1979, three brothers had antibody titers for toxoplasmosis of 1:1,024, 1:64, and 1:16, respectively, by IgG indirect immunofluorescent antibody (IgG-IFA) test. The first child also had a fever and lymphadenopathy. In August 1980 the three children had lymphadenopathy and IgG-IFA test titers between 1:4,096 and 1:16,000. Two other brothers, first examined at that time, had IgG-IFA test titers between 1:1,024 and 1:4,096, one with ascending titers and the other with IgM antibodies to Toxoplasma gondii. The latter had lymphadenopathy, fever, and hepatosplenomegaly. Clinical and serologic examinations during March, April, and September 1981 revealed good health and decreasing IgG-IFA test titers in most of the brothers. The simultaneous increase of antibody titers during August 1980 in the three initial patients lead to the consideration of a probable reinfection. A simultaneous reactivation of the disease was considered less probable because acute toxoplasmosis occurred in two other brothers at the same time.
1979年期间，通过IgG间接免疫荧光抗体（IgG-IFA）检测，三兄弟的弓形虫病抗体滴度分别为1:1024、1:64和1:16。第一个孩子还伴有发热和淋巴结病。1980年8月，这三个孩子出现淋巴结病，IgG-IFA检测滴度在1:4096至1:16000之间。另外两个兄弟在当时首次接受检查，其IgG-IFA检测滴度在1:1024至1:4096之间，其中一人滴度上升，另一人有抗刚地弓形虫的IgM抗体。后者伴有淋巴结病、发热和肝脾肿大。1981年3月、4月和9月的临床及血清学检查显示，大多数兄弟身体健康，IgG-IFA检测滴度下降。1980年8月，最初的三名患者抗体滴度同时升高，这使得人们考虑可能发生了再次感染。由于另外两名兄弟同时发生了急性弓形虫病，因此认为疾病同时重新激活的可能性较小。
