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霍奇金病中的纤维蛋白沉积。

Fibrin deposits in Hodgkin's disease.

作者信息

Harris N L, Dvorak A M, Smith J, Dvorak H F

出版信息

Am J Pathol. 1982 Jul;108(1):119-29.

PMID:7046453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1916024/
Abstract

Fibrin deposits were observed in the involved lymph nodes and/or spleens of 15 patients with Hodgkin's disease by specific immunofluorescence and by electron microscopy. Two basic patterns of fibrin deposition were observed: 1) intercellular deposits, chiefly associated with nonneoplastic-appearing lymphoid cells and 2) deposits associated with the collagen fibers of young connective tissue. In addition, coarse fibrin deposits were observed in areas of necrosis, presumably a non-specific finding. Fibronectin was also observed in intercellular areas, but staining was less intense than for fibrin. Fibrin deposits were also observed in 3 of 6 cases of non-Hodgkin's lymphoma, indicating that the finding is not an exclusive feature of Hodgkin's disease. The pathogenesis and possible significance of fibrin deposition in Hodgkin's disease are related to earlier observations of activation of the coagulation system on neoplasia and cell-mediated immunity and to the possible role of fibrin, fibronectin, and their breakdown products in angiogenesis and fibroplasia.

摘要

通过特异性免疫荧光和电子显微镜观察，在15例霍奇金病患者受累的淋巴结和/或脾脏中发现了纤维蛋白沉积。观察到两种基本的纤维蛋白沉积模式：1）细胞间沉积，主要与外观无肿瘤特征的淋巴细胞相关；2）与年轻结缔组织的胶原纤维相关的沉积。此外，在坏死区域观察到粗大的纤维蛋白沉积，这可能是一个非特异性发现。在细胞间区域也观察到纤连蛋白，但染色强度低于纤维蛋白。在6例非霍奇金淋巴瘤中，有3例也观察到纤维蛋白沉积，这表明该发现并非霍奇金病的独有特征。霍奇金病中纤维蛋白沉积的发病机制及可能意义与先前关于肿瘤形成时凝血系统激活和细胞介导免疫的观察结果有关，也与纤维蛋白、纤连蛋白及其降解产物在血管生成和纤维形成中可能发挥 的作用有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/8027feb67b34/amjpathol00202-0131-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/2959c27857ef/amjpathol00202-0128-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/b1fb623cfbac/amjpathol00202-0128-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/fc67e42f91ea/amjpathol00202-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/a61bc85c6ad4/amjpathol00202-0126-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/a03fadb41de4/amjpathol00202-0127-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/640a371485ab/amjpathol00202-0129-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/c5972f48d495/amjpathol00202-0130-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/8027feb67b34/amjpathol00202-0131-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/2959c27857ef/amjpathol00202-0128-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/b1fb623cfbac/amjpathol00202-0128-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/fc67e42f91ea/amjpathol00202-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/a61bc85c6ad4/amjpathol00202-0126-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/a03fadb41de4/amjpathol00202-0127-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/640a371485ab/amjpathol00202-0129-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/c5972f48d495/amjpathol00202-0130-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/1916024/8027feb67b34/amjpathol00202-0131-a.jpg

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本文引用的文献

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Fibrin in human tumors.人类肿瘤中的纤维蛋白。
Cancer Res. 1960 Jun;20:592-3.
2
Localization of radioiodinated rat fibrinogen in transplanted rat tumors.放射性碘化大鼠纤维蛋白原在移植大鼠肿瘤中的定位
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On the pathogenesis of sclerosis and nodularity in nodular sclerosing Hodgkin's disease.关于结节硬化型霍奇金淋巴瘤中硬化和结节形成的发病机制。
凝血因子 XIII-A 在疾病中的作用：超越血液凝固的角色。
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Regulation of fibrin deposition by malignant mesothelioma.恶性间皮瘤对纤维蛋白沉积的调节作用。
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5
The distribution of fibronectin in lymph nodes infiltrated by Hodgkin's disease. An immunoperoxidase study on paraffin sections.霍奇金病浸润淋巴结中纤连蛋白的分布。石蜡切片的免疫过氧化物酶研究。
Virchows Arch A Pathol Anat Histopathol. 1983;400(3):319-29. doi: 10.1007/BF00612193.
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Fibrin as a component of the tumor stroma: origins and biological significance.纤维蛋白作为肿瘤基质的组成部分：起源与生物学意义
Cancer Metastasis Rev. 1983;2(1):41-73. doi: 10.1007/BF00046905.
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Characterization of factor XIII containing-macrophages in lymph nodes with Hodgkin's disease.霍奇金病淋巴结中含凝血因子XIII巨噬细胞的特征分析
Br J Cancer. 1987 Apr;55(4):421-6. doi: 10.1038/bjc.1987.82.
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Fibrinogen influx and accumulation of cross-linked fibrin in healing wounds and in tumor stroma.纤维蛋白原流入以及交联纤维蛋白在愈合伤口和肿瘤基质中的积累。
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9
Morphological and immunohistochemical studies of Hodgkin's disease in the spleen.脾脏中霍奇金淋巴瘤的形态学和免疫组织化学研究。
Virchows Arch A Pathol Anat Histopathol. 1989;415(5):429-36. doi: 10.1007/BF00747744.
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Inhibition by fibrin coagulation of lung cancer cell destruction by human interleukin-2-activated killer cells.纤维蛋白凝血对人白细胞介素-2激活的杀伤细胞破坏肺癌细胞的抑制作用。
Jpn J Cancer Res. 1992 Oct;83(10):1088-94. doi: 10.1111/j.1349-7006.1992.tb02726.x.
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Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment.纤连蛋白诱导成纤维细胞趋化性。趋化区域定位于一个分子量为140,000的非明胶结合片段。
J Exp Med. 1981 Feb 1;153(2):494-9. doi: 10.1084/jem.153.2.494.
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Tumor shedding and coagulation.肿瘤脱落与凝血
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Fibronectin in delayed-type hypersensitivity skin reactions: associations with vessel permeability and endothelial cell activation.迟发型超敏反应皮肤反应中的纤连蛋白：与血管通透性及内皮细胞活化的关联
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Reed-Sternberg cells in Hodgkin's disease contain fibronectin.霍奇金病中的里德-施特恩伯格细胞含有纤连蛋白。
Blood. 1981 Feb;57(2):339-42.
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Sequential appearance of fibronectin and collagen in experimental granulation tissue.实验性肉芽组织中纤连蛋白和胶原蛋白的相继出现。
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