Fabricant R, Salisbury J D, Berkowitz R A, Kaufman H E
Arch Ophthalmol. 1982 Jun;100(6):994-5. doi: 10.1001/archopht.1982.01030031002022.
Epidermal growth factor (EGF) was injected into the anterior chambers of 12 rhesus monkeys after the denudation of the central corneal endothelium during autograft transplantation. The animals were treated both at the time of surgery and three weeks after surgery. Clinical appearance and corneal thickness were monitored until the corneas were removed by penetrating keratoplasty ten weeks after the initial treatment. Flat preparations of the corneas showed significantly more endothelial cells in the central corneas of the EGF-treated eyes compared with the control eyes. These findings indicate that EGF is effective in replenishing the corneal endothelium after injury.
在自体移植手术中对12只恒河猴的中央角膜内皮进行剥脱后，将表皮生长因子（EGF）注入其前房。在手术时和术后三周对这些动物进行治疗。监测其临床表现和角膜厚度，直至在初始治疗十周后通过穿透性角膜移植术摘除角膜。角膜的平铺标本显示，与对照眼相比，接受EGF治疗的眼睛中央角膜中的内皮细胞明显更多。这些发现表明，EGF在损伤后补充角膜内皮方面是有效的。
