Champsaur H, Adremont A, Mathieu D, Rottman E, Auzepy P
J Infect Dis. 1982 Feb;145(2):248-54. doi: 10.1093/infdis/145.2.248.
A Thai woman from Bangkok was admitted to a hospital in Paris for a cholera-like illness. A culture of her "rice-water" diarrhea was negative for Vibrio cholerae and enterotoxigenic Escherichia coli but was positive for Aeromonas sobria. This strain produced enterotoxin, cytolysin, proteolysin, hemolysin, and a cell-rounding factor. Acute -and convalescent-phase sera showed an increase in neutralizing antibodies to enterotoxin, cytolysin, and hemolysin. The enterotoxin, which was labile at 100 C, induced an accumulation of fluid in the rabbit ileal loop model and was not neutralized by antiserum to cholera toxin. Suckling mouse assays and rabbit permeability skin tests were negative, and the Y1 mouse adrenal cell assay produced not true cytotonic effect. This report, the first of an infection due to A. sobria alone, provides evidence that A. sobria is an enteric pathogen of humans that can cause a toxin-mediated, life-threatening illness.
一名来自曼谷的泰国女性因类似霍乱的疾病被送往巴黎的一家医院。对其“米汤样”腹泻物进行培养，霍乱弧菌和产肠毒素大肠杆菌检测呈阴性，但温和气单胞菌检测呈阳性。该菌株产生肠毒素、细胞毒素、蛋白水解酶、溶血素和一种使细胞变圆的因子。急性期和恢复期血清显示，针对肠毒素、细胞毒素和溶血素的中和抗体增加。这种肠毒素在100℃时不稳定，在兔回肠袢模型中可引起液体蓄积，且不能被霍乱毒素抗血清中和。乳鼠试验和兔皮肤通透性试验均为阴性，Y1小鼠肾上腺细胞试验未产生真正的细胞紧张效应。本报告首次报道了单独由温和气单胞菌引起的感染，证明温和气单胞菌是一种可导致毒素介导的危及生命疾病的人类肠道病原体。
