DNA序列同源性的二维图形分析
Two-dimensional graphic analysis of DNA sequence homologies.
作者信息
Harr R, Hagblom P, Gustafsson P
出版信息
Nucleic Acids Res. 1982 Jan 11;10(1):365-74. doi: 10.1093/nar/10.1.365.
Abstract
We describe a computer program designed to facilitate the pattern matching analysis of homologies between DNA sequences. It takes advantage of a two-dimensional plot in order to simplify the evaluation of significant structures inherited in the sequences. The program can be divided into three parts, i) algorithm for search of homologies, ii) two-dimensional graphic display of the result, iii) further graphic treatment to enhance significant structures. The power of the graphic display is presented by the following application of the program. We conducted a search for direct repeats in the mouse immunoglobulin kappa-chain genes. Both the five J DNA sequences and other shorter repeats were found. We also found a longer stretch of homology that could indicate the presence of duplicated DNA in the J4, J5 region.
摘要
我们描述了一个旨在促进DNA序列同源性模式匹配分析的计算机程序。它利用二维图来简化对序列中遗传的重要结构的评估。该程序可分为三个部分：i）同源性搜索算法，ii）结果的二维图形显示，iii）进一步的图形处理以增强重要结构。该程序的以下应用展示了图形显示的强大功能。我们对小鼠免疫球蛋白κ链基因中的直接重复序列进行了搜索。发现了五个J DNA序列以及其他较短的重复序列。我们还发现了一段更长的同源性序列，这可能表明J4、J5区域存在重复的DNA。
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