用于DNA序列组装的计算机程序。
Computer programs for the assembly of DNA sequences.
作者信息
Gingeras T R, Milazzo J P, Sciaky D, Roberts R J
出版信息
Nucleic Acids Res. 1979 Sep 25;7(2):529-45. doi: 10.1093/nar/7.2.529.
Abstract
A collection of user-interactive computer programs is described which aid in the assembly of DNA sequences. This is achieved by searching for the positions of overlapping common nucleotide sequences within the blocks of sequence obtained as primary data. Such overlapping segments are then melded into one continuous string of nucleotides. Strategies for determining the accuracy of the sequence being analyzed and reducing the error rate resulting from the manual manipulation of sequence data are discussed. Sequences mapping from 97.3 to 100% of the Ad2 virus genome were used to demonstrate the performance of these programs.
摘要
描述了一组用户交互式计算机程序，这些程序有助于DNA序列的组装。这是通过在作为原始数据获得的序列块内搜索重叠的共同核苷酸序列的位置来实现的。然后将这些重叠片段融合成一个连续的核苷酸链。讨论了确定所分析序列准确性和降低因手动处理序列数据而导致的错误率的策略。使用映射到腺病毒2型（Ad2）病毒基因组97.3%至100%的序列来证明这些程序的性能。
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