Dodson P M, Galton D J, Hamilton A M, Blach R K
Br J Ophthalmol. 1982 Mar;66(3):161-4. doi: 10.1136/bjo.66.3.161.
Ninety-nine patients with retinal vein occlusion (40 with central, 59 with branch vein occlusion) were investigated for the prevalence of associated diseases for comparison with an age-matched control group. There was a significantly increased prevalence of hyperlipidaemia (p less than 0.001) and hypercholesterolaemia (p less than 0.001) in the group with branch retinal vein occlusion and of hyperlipidaemia (p less than 0.001) and hypercholesterolaemia (p less than 0.02) in the group with central retinal vein occlusion compared with controls. An increased prevalence of hypertriglyceridaemia (p less than 0.001) was also found in patients with central vein occlusion. Other associations were noted (hypertension and oestrogen therapy). Increased serum cholesterol concentrations were found in patients with central vein occlusion (p less than 0.05) and branch vein occlusion (p less than 0.001) compared with controls, and similar tendencies were noted for levels of LDL and HDL cholesterol. Patients with central vein occlusion also had raised levels of serum triglyceride (p less than 0.001) and VLDL-triglyceride (p less than 0.05). The occurrence of both central and branch vein occlusions may be associated with an increased prevalence of hyperlipidaemia and hypertension. Increase of serum lipids may contribute to the aetiology of vein occlusion by altering plasma viscosity or affecting platelet function.
对99例视网膜静脉阻塞患者（40例为中央静脉阻塞，59例为分支静脉阻塞）进行相关疾病患病率调查，以与年龄匹配的对照组作比较。与对照组相比，视网膜分支静脉阻塞组的高脂血症（p<0.001）和高胆固醇血症（p<0.001）患病率显著升高，视网膜中央静脉阻塞组的高脂血症（p<0.001）和高胆固醇血症（p<0.02）患病率也显著升高。中央静脉阻塞患者的高甘油三酯血症患病率也有所增加（p<0.001）。还发现了其他相关性（高血压和雌激素治疗）。与对照组相比，中央静脉阻塞患者（p<0.05）和分支静脉阻塞患者（p<0.001）的血清胆固醇浓度升高，低密度脂蛋白和高密度脂蛋白胆固醇水平也有类似趋势。中央静脉阻塞患者的血清甘油三酯（p<0.001）和极低密度脂蛋白甘油三酯（p<0.05）水平也升高。中央静脉阻塞和分支静脉阻塞的发生可能都与高脂血症和高血压患病率增加有关。血脂升高可能通过改变血浆粘度或影响血小板功能而导致静脉阻塞的病因。
