Cole D E, Shafai J, Scriver C R
Clin Chim Acta. 1982 Mar 26;120(1):153-9. doi: 10.1016/0009-8981(82)90086-9.
Inorganic sulfate in cerebrospinal fluid (CSF) from 25 infants and children was measured by controlled-flow anion chromatography. The mean CSF concentration was 0.133 +/- 0.066 mumol/l for the group. Mean CSF sulfate is age dependent being 0.170 mmol/l in the newborn and 0.095 mmol/l (range: 0.059-0.165) in children over 3 years of age. The fall in CSF sulfate parallels a corresponding age-dependent change in serum sulfate. Accordingly, the CSF:serum ratio (0.334 +/- 0.019; mean +/- SE) remains constant in infants and children. The CSF:serum ratio departs significantly from that predicted by the Gibbs-Donnan equilibrium relation (predicted ratio, 1.21). CSF sulfate content appears to reflect mediated transport of sulfate out of CSF.
采用控制流阴离子色谱法测定了25例婴幼儿脑脊液（CSF）中的无机硫酸盐。该组脑脊液的平均浓度为0.133±0.066μmol/l。脑脊液中硫酸盐的平均值与年龄有关，新生儿为0.170mmol/l，3岁以上儿童为0.095mmol/l（范围：0.059 - 0.165）。脑脊液中硫酸盐的下降与血清中硫酸盐相应的年龄依赖性变化平行。因此，婴幼儿脑脊液与血清的比值（0.334±0.019；平均值±标准误）保持恒定。脑脊液与血清的比值与吉布斯-唐南平衡关系预测的值（预测比值为1.21）有显著差异。脑脊液中硫酸盐的含量似乎反映了硫酸盐从脑脊液中的介导转运。
