Niehaus C E, Nicoll A, Wootton R, Williams B, Lewis J, Coltart D J, Lewis B
Lancet. 1977 Sep 3;2(8036):469-71. doi: 10.1016/s0140-6736(77)91600-2.
Transfer of low-density lipoprotein (L.D.L.2) from plasma to arterial intima was studied in 16 patients undergoing arterial surgery. Autologous labelled lipoprotein was used to demonstrate that L.D.L.2 enters the intima from plasma. Net flux of L.D.L.2 appeared to increase with age. Within each age-group the net flux of L.D.L.2 showed a pronounced positive correlation with plasma-L.D.L.-cholesterol concentrations. This may account in part for the association between hypercholesterolaemia and the development of atherosclerosis.
对16例接受动脉手术的患者研究了低密度脂蛋白（L.D.L.2）从血浆到动脉内膜的转运情况。使用自体标记的脂蛋白来证明L.D.L.2从血浆进入内膜。L.D.L.2的净通量似乎随年龄增加。在每个年龄组中，L.D.L.2的净通量与血浆L.D.L.胆固醇浓度呈显著正相关。这可能部分解释了高胆固醇血症与动脉粥样硬化发展之间的关联。
