Marmor M, Willeberg P, Glickman L T, Priester W A, Cypess R H, Hurvitz A I
Am J Vet Res. 1982 Mar;43(3):465-70.
A case-control study of spontaneous diabetes mellitus in dogs was undertaken, using 2 veterinary data bases. The Veterinary Medical Data Program (VMDP) contained records of 1,019 cases of canine diabetes from 14 university-affiliated veterinary hospitals. The Animal Medical Center (AMC), a private veterinary hospital which has not participated in the VMDP, contained records of 449 diabetes cases. Each data base was analyzed separately, control groups being chosen from all admissions, excluding diabetic animals. Summary odds ratios by sex adjusted for age and breed indicated significantly (P less than 0.05) elevated risks for entire females and neutered females compared with that for entire males. The VMDP data indicated a significantly elevated risk for castrated males, whereas the risk derived from AMC data was not significantly different from 1. Analysis of risks by breed adjusting for age and sex identified Poodles as being at significantly excess risk, and German Shepherd Dogs, Cocker Spaniels, Collies, and Boxers at significantly decreased risk in both data sets. The male-female risk ratio changed with age from 1 at less than 1 year of age to a predominance of females at older ages. In the AMC data base, diabetes was significantly associated with cataracts in dogs of both sexes combined. Diabetes was also significantly associated with benign mammary tumors in female dogs.
利用两个兽医数据库对犬自发性糖尿病进行了病例对照研究。兽医医学数据项目（VMDP）包含来自14家大学附属兽医医院的1019例犬糖尿病记录。动物医疗中心（AMC）是一家未参与VMDP的私立兽医医院，包含449例糖尿病病例记录。每个数据库分别进行分析，对照组从所有入院病例中选取，但不包括糖尿病动物。按年龄和品种调整后的性别汇总比值比表明，与未绝育雄性犬相比，未绝育雌性犬和绝育雌性犬的风险显著升高（P<0.05）。VMDP数据表明去势雄性犬的风险显著升高，而AMC数据得出的风险与1无显著差异。按年龄和性别调整后的品种风险分析表明，两个数据集中贵宾犬的风险显著过高，德国牧羊犬、可卡犬、柯利犬和拳师犬的风险显著降低。雌雄风险比随年龄变化，1岁以下时为1，年龄较大时雌性占主导。在AMC数据库中，糖尿病与雌雄犬的白内障显著相关。糖尿病还与雌性犬的良性乳腺肿瘤显著相关。
