Goto H, Shimizu K, Taya Y, Noda H, Tokunaga T
Can J Comp Med. 1982 Jan;46(1):27-32.
The antibody responses to equine influenza viruses were investigated during a postepizootic period of the disease. Serum samples were collected from a total of 128 horses on three occasions during the years 1967-77. No significant increase of hemagglutination-inhibition antibody titers to subtypes 1 and 2 of equine influenza virus were detected in any of the sera tested. The maternal hemagglutination-inhibition antibody titers of foals decreased over a four month interval. A marked increase of the titers was recognized in only the equine influenza virus vaccinated horses. These findings suggest that equine influenza virus was not prevalent in the horse populations during the observation period. In such conditions, the dissemination of equine influenza viruses in the horses is discussed in relation to introduction of the disease from abroad. We also examined whether the doctrine of original antigenic sin, an immunological phenomenon recognized in human influenza, was applicable for equine influenza. However, no marked increase of hemagglutination-inhibition antibody titer to the primary infecting subtype in the 44 horses was observed after administration of the heterologous subtype vaccine.
在马流感疾病的一次流行后期，对马流感病毒的抗体反应进行了调查。在1967年至1977年期间，分三次从总共128匹马身上采集了血清样本。在所检测的任何血清中，均未检测到针对马流感病毒1型和2型的血凝抑制抗体滴度有显著增加。驹的母源血凝抑制抗体滴度在四个月的间隔期内下降。仅在接种马流感病毒疫苗的马匹中观察到滴度有明显增加。这些发现表明，在观察期内马流感病毒在马群中并不流行。在这种情况下，结合从国外引入该疾病的情况，讨论了马流感病毒在马中的传播。我们还研究了在人类流感中被认可的一种免疫现象——原始抗原罪学说是否适用于马流感。然而，在给44匹马接种异源亚型疫苗后，未观察到针对初次感染亚型的血凝抑制抗体滴度有明显增加。
