BenEzra D
Am J Ophthalmol. 1978 Oct;86(4):455-61. doi: 10.1016/0002-9394(78)90289-1.
Prostaglandins E1, E2, D2, A1, F1alpha, and F2alpha as well as synthetic chemoattractants and growth factors were tested for their ability to induce the proliferation of new blood vessels in the rabbit cornea. PGE1 showed the strongest neovasculogenic activity attracting new blood vessels in all of the cases. PGE2 was a weaker attractant than PGE1. PGF2alpha induced a less consistent reaction. All implants sequestering PGD2 or PGA1 were negative. Implants sequestering 1 microgram of fibroblast growth factor or epidermal growth factor variably stimulated the proliferation of keratocytes and epithelial cells in vivo. However, none of these demonstrated any vasculogenic activity. A small, but significant neovascularization was observed only in implants sequestering 10 microgram of growth factor per implant. Although active in vitro, nerve growth factor and formylated synthetic peptides were not stimulatory in vivo.
对前列腺素E1、E2、D2、A1、F1α和F2α以及合成趋化因子和生长因子诱导兔角膜新生血管增殖的能力进行了测试。在所有情况下，PGE1显示出最强的新生血管生成活性，能吸引新生血管。PGE2作为吸引剂比PGE1弱。PGF2α诱导的反应不太一致。所有含有PGD2或PGA1的植入物均呈阴性。含有1微克成纤维细胞生长因子或表皮生长因子的植入物在体内可不同程度地刺激角膜细胞和上皮细胞的增殖。然而，这些均未表现出任何血管生成活性。仅在每个植入物含有10微克生长因子的植入物中观察到少量但显著的新生血管形成。尽管神经生长因子和甲酰化合成肽在体外有活性，但在体内无刺激作用。
