Egg D, Altmann H, Günther R, Klein W, Kocsis F
Prostaglandins. 1978 Mar;15(3):437-46. doi: 10.1016/0090-6980(78)90127-2.
In vitro experiments were performed on mouse spleen cells to establish possible influences of some naturally occurring prostaglandins on DNA synthesis and DNA excision repair. The prostaglandins A1, B1, E1, E2 and F2alpha were tested in concentrations of lopg, 5ng and 2.5microgram per ml cell suspension. DNA synthesis was significantly increased by PgF2alpha in all the three concentrations tested, while the other tested prostaglandins were essentially ineffective. DNA excision repair was significantly inhibited by PgE1 and PgE2 at 5ng/ml and at 2.5microgram/ml but increased by PgF2alpha in the two lower concentrations. The rejoining of DNA-strand breaks after gamma-irradiation was slightly reduced by PgE1, PgE2 and PgF2alpha at 2.5microgram/ml.
在小鼠脾细胞上进行了体外实验，以确定某些天然存在的前列腺素对DNA合成和DNA切除修复的可能影响。对前列腺素A1、B1、E1、E2和F2α进行了测试，细胞悬液中每毫升的浓度分别为10pg、5ng和2.5微克。在所测试的三种浓度下，PgF2α均显著增加了DNA合成，而其他所测试的前列腺素基本无效。在5ng/ml和2.5微克/ml时，PgE1和PgE2显著抑制了DNA切除修复，但在两个较低浓度下，PgF2α则使其增加。在2.5微克/ml时，PgE1、PgE2和PgF2α使γ射线照射后DNA链断裂的重新连接略有减少。
